B
Bernard Ducommun
Researcher at University of Toulouse
Publications - 158
Citations - 9562
Bernard Ducommun is an academic researcher from University of Toulouse. The author has contributed to research in topics: Cell cycle & Cdc25. The author has an hindex of 48, co-authored 158 publications receiving 9065 citations. Previous affiliations of Bernard Ducommun include Centre national de la recherche scientifique & Centre Hospitalier Universitaire de Toulouse.
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Journal ArticleDOI
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy.
Cécile Delettre,Guy Lenaers,Jean-Michel Griffoin,Nadine Gigarel,Corinne Lorenzo,Pascale Belenguer,Laetitia Pelloquin,J. Grosgeorge,Claude Turc-Carel,Eric Perret,Catherine Astarie-Dequeker,Laetitia Lasquellec,B. Arnaud,Bernard Ducommun,Josseline Kaplan,Christian P. Hamel +15 more
TL;DR: A nuclear gene, OPA1, is described here a nuclear gene that maps within the candidate region and encodes a dynamin-related protein localized to mitochondria, demonstrating a role for mitochondria in retinal ganglion cell pathophysiology.
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CDC25 phosphatases in cancer cells: key players? Good targets?
TL;DR: The roles of CDC25 phosphatases in both normal and abnormal cell proliferation are focused on, a critical assessment of the current data on CDC25 overexpression in cancer is provided, and both current and future therapeutic strategies for targeting CDC25 activity in cancer treatment are discussed.
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The when and wheres of CDC25 phosphatases.
TL;DR: Recent data demonstrate that in addition to the ATM/ATR-CHK pathway, a p38-MAPKAP pathway is also involved in controlling CDC25 activity during G(2)/M checkpoint activation and highlight the significance of developing specific CDC25 inhibitors for cancer therapy.
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The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space.
Aurélien Olichon,Laurent J. Emorine,Eric Descoins,Laetitia Pelloquin,Laetitia Brichese,Nicole Gas,Emmanuelle Guillou,Cécile Delettre,Annie Valette,Christian P. Hamel,Bernard Ducommun,Guy Lenaers,Pascale Belenguer +12 more
TL;DR: Immuno‐fluorescence and biochemical evidences are presented showing that OPA1 resides in the mitochondria where it is imported through its highly basic amino‐terminal extension.
Journal ArticleDOI
p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells
TL;DR: In this paper, the effects of p21/PCNA interaction on cell cycle progression were investigated using a tetracycline-regulated system, and it was shown that expression of wild-type p21 in p53-deficient DLD1 human colon cancer cells inhibits DNA synthesis and causes G1 and G2 cell cycle arrest.