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Audrey Lorthiois
Researcher at Pierre-and-Marie-Curie University
Publications - 11
Citations - 433
Audrey Lorthiois is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 8, co-authored 9 publications receiving 348 citations. Previous affiliations of Audrey Lorthiois include French Institute of Health and Medical Research & Paris Descartes University.
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Journal ArticleDOI
Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice.
Valérie Soulard,Valérie Soulard,Valérie Soulard,Henriette Bosson-Vanga,Audrey Lorthiois,Clémentine Roucher,Clémentine Roucher,Clémentine Roucher,Jean François Franetich,Jean François Franetich,Jean François Franetich,Gigliola Zanghi,Gigliola Zanghi,Gigliola Zanghi,Mallaury Bordessoulles,Mallaury Bordessoulles,Mallaury Bordessoulles,Maurel Tefit,Maurel Tefit,Maurel Tefit,Marc Thellier,Serban Morosan,Gilles Le Naour,Frédérique Capron,Hiroshi Suemizu,Georges Snounou,Georges Snounou,Georges Snounou,Alicia Moreno-Sabater,Alicia Moreno-Sabater,Alicia Moreno-Sabater,Dominique Mazier +31 more
TL;DR: It is shown that human hepatocytes engrafted in TK-NOG mice sustain maturation of the liver stages, and the presence of late-developing schizonts indicate the eventual activation of quiescent parasites.
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cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission.
Ghania Ramdani,Bernina Naissant,Eloise Thompson,Florence Breil,Audrey Lorthiois,Florian Dupuy,Ross M Cummings,Yoann Duffier,Yolanda Corbett,Odile Mercereau-Puijalon,Kenneth D. Vernick,Donatella Taramelli,David A. Baker,Gordon Langsley,Catherine Lavazec +14 more
TL;DR: Pharmacological agents that raise cAMP levels in transmissible stage V gametocytes render them less deformable and hence less likely to circulate through the spleen, and represent new candidate drugs to block transmission of malaria parasites, such as sildenafil.
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A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites
Ben C. L. van Schaijk,Ivo H J Ploemen,Takeshi Annoura,Martijn W. Vos,Lander Foquet,Geert-Jan van Gemert,Severine Chevalley-Maurel,Marga van de Vegte-Bolmer,Mohammed Sajid,Jean-François Franetich,Audrey Lorthiois,Geert Leroux-Roels,Philip Meuleman,Cornelius C Hermsen,Dominique Mazier,Stephen L. Hoffman,Chris J. Janse,Shahid M. Khan,Robert W. Sauerwein +18 more
TL;DR: Data on safety and protective efficacy using sporozoites with deletions of two genes, that is the newly identified b9 and slarp, which govern independent and critical processes for successful liver-stage development are presented and support the clinical development of a PfΔb9ΔslarpSPZ vaccine.
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Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.
Daniel Y. Bargieri,Daniel Y. Bargieri,Sabine Thiberge,Chwen L. Tay,Alison F. Carey,Alison F. Carey,Alice Rantz,Florian Hischen,Audrey Lorthiois,Ursula Straschil,Pallavi Singh,Shailja Singh,Tony Triglia,Takafumi Tsuboi,Alan F. Cowman,Alan F. Cowman,Chetan E. Chitnis,Pietro Alano,Jake Baum,Gabriele Pradel,Catherine Lavazec,Robert Ménard +21 more
TL;DR: Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apicomplexan parasites, indicating that motor-binding TRAP family members function not just in parasite motility and cell invasion but also in membrane disruption and cell egress.
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Plasmodium falciparum STEVOR phosphorylation regulates host erythrocyte deformability enabling malaria parasite transmission
Bernina Naissant,Florian Dupuy,Yoann Duffier,Audrey Lorthiois,Julien Duez,Judith A. M. Scholz,Pierre Buffet,Anais Merckx,Anais Merckx,Anna Bachmann,Catherine Lavazec +10 more
TL;DR: Evidence is produced that the increase of GIE stiffness induced by sildenafil (Viagra) is dependent on STEVOR phosphorylation status and on another independent mechanism, and new insights are provided into mechanisms by which phosphodiesterase inhibitors may block malaria parasite transmission.