C
Cécile Gouttefangeas
Researcher at University of Tübingen
Publications - 140
Citations - 5565
Cécile Gouttefangeas is an academic researcher from University of Tübingen. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 35, co-authored 126 publications receiving 4555 citations. Previous affiliations of Cécile Gouttefangeas include French Institute of Health and Medical Research & German Cancer Research Center.
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Journal ArticleDOI
Actively personalized vaccination trial for newly diagnosed glioblastoma
Norbert Hilf,Sabrina Kuttruff-Coqui,Katrin Frenzel,Valesca Bukur,Stefan Stevanovic,Stefan Stevanovic,Cécile Gouttefangeas,Cécile Gouttefangeas,Michael Platten,Michael Platten,Ghazaleh Tabatabai,Ghazaleh Tabatabai,Valérie Dutoit,Sjoerd H. van der Burg,Per thor Straten,Per thor Straten,Francisco Martínez-Ricarte,Berta Ponsati,Hideho Okada,Ulrik Lassen,Arie Admon,Christian H. Ottensmeier,Alexander Ulges,Sebastian Kreiter,Andreas von Deimling,Andreas von Deimling,Marco Skardelly,Denis Migliorini,Judith R. Kroep,Manja Idorn,Manja Idorn,Jordi Rodon,Jordi Rodon,Jordi Piro,Hans Skovgaard Poulsen,Bracha Shraibman,Katy J. McCann,Regina Mendrzyk,Martin Löwer,Monika Stieglbauer,Cedrik M. Britten,David Capper,David Capper,David Capper,Marij J. P. Welters,Juan Sahuquillo,Katharina Kiesel,Evelyna Derhovanessian,Elisa Rusch,Lukas Bunse,Lukas Bunse,Colette Song,Sandra Heesch,Claudia Wagner,Alexandra Kemmer-Brück,Jorg Ludwig,John C. Castle,Oliver Schoor,Arbel D. Tadmor,Edward W. Green,Jens Fritsche,Miriam Meyer,Nina Pawlowski,Sonja Dorner,Franziska Hoffgaard,Bernhard Rossler,Dominik Maurer,Toni Weinschenk,Carsten Reinhardt,Christoph Huber,Hans-Georg Rammensee,Hans-Georg Rammensee,Harpreet Singh-Jasuja,Ugur Sahin,Pierre-Yves Dietrich,Wolfgang Wick,Wolfgang Wick +76 more
TL;DR: In a phase I trial, highly individualized peptide vaccines against unmutated tumour antigens and neoepitopes elicited sustained responses in CD8+ and CD4+ T cells, respectively, in patients with newly diagnosed glioblastoma.
Journal ArticleDOI
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition.
Annika Nelde,Tatjana Bilich,Jonas S. Heitmann,Yacine Maringer,Helmut R. Salih,Helmut R. Salih,Malte Roerden,Maren Lübke,Jens Bauer,Jonas Rieth,Marcel Wacker,Andreas Peter,Sebastian Hörber,Bjoern Traenkle,Philipp D. Kaiser,Ulrich Rothbauer,Matthias Becker,Daniel Junker,Gérard Krause,Monika Strengert,Nicole Schneiderhan-Marra,Markus F. Templin,Thomas O. Joos,Daniel J. Kowalewski,Vlatka Stos-Zweifel,Michael Fehr,Armin Rabsteyn,Armin Rabsteyn,Valbona Mirakaj,Julia Karbach,Elke Jäger,Michael Graf,Lena Christin Gruber,David Rachfalski,Beate Preuß,Ilona Hagelstein,Melanie Märklin,Tamam Bakchoul,Cécile Gouttefangeas,Cécile Gouttefangeas,Oliver Kohlbacher,Reinhild Klein,Stefan Stevanovic,Stefan Stevanovic,Hans-Georg Rammensee,Hans-Georg Rammensee,Juliane S. Walz +46 more
TL;DR: This work identifies and characterize multiple dominant and subdominant SARS-CoV-2 HLA class I and HLA-DR peptides as potential T cell epitopes in COVID-19 convalescent and unexposed individuals to enable identification of heterologous and post-infectious T cell immunity and facilitate development of diagnostic, preventive and therapeutic measures for CO VID-19.
Journal Article
Integrated functional genomics approach for the design of patient-individual antitumor vaccines.
Toni Weinschenk,Cécile Gouttefangeas,Markus Schirle,Florian Obermayr,Steffen Walter,Oliver Schoor,Raffael Kurek,Wolfgang Loeser,Karl-Horst Bichler,Dorothee Wernet,Stefan Stevanovic,Hans-Georg Rammensee +11 more
TL;DR: It is shown that by combining these two analytic tools, it is possible to propose several candidates for peptide-based immunotherapy and envision the use of this novel integrated functional genomics approach for the design of antitumor vaccines tailored to suit the needs of each patient.
Journal ArticleDOI
Cytomegalovirus infection: a driving force in human T cell immunosenescence.
Sven D. Koch,Anis Larbi,Dennis Özcelik,Rafael Solana,Cécile Gouttefangeas,Sebastian Attig,Anders Wikby,Jan Strindhall,Claudio Franceschi,Graham Pawelec +9 more
TL;DR: Findings support the hypothesis that persistent herpesviruses, especially CMV, act as chronic antigenic stressors and play a major causative role in immunosenescence and associated mortality.
Journal ArticleDOI
More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer
Sebastian P. Haen,Philippe L. Pereira,Helmut R. Salih,Hans-Georg Rammensee,Cécile Gouttefangeas +4 more
TL;DR: Findings on immune modulation through radiofrequency ablation, cryoablation, microwave ablation therapy, high-intensity focused ultrasound, and laser-induced thermotherapy are summarized.