Oliver Kohlbacher

TL;DR: This study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and it reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.

TL;DR: Feature-based molecular networking (FBMN) as discussed by the authors is an analysis method in the Global Natural Products Social Molecular Networking (GNPS) infrastructure that builds on chromatographic feature detection and alignment tools.

TL;DR: This work identifies and characterize multiple dominant and subdominant SARS-CoV-2 HLA class I and HLA-DR peptides as potential T cell epitopes in COVID-19 convalescent and unexposed individuals to enable identification of heterologous and post-infectious T cell immunity and facilitate development of diagnostic, preventive and therapeutic measures for CO VID-19.

TL;DR: The study demonstrates broad cellular effects of SARS-CoV-2 infection beyond classical immune cells and may serve as an entry point to develop biomarkers and targeted treatments of patients with COVID-19.

TL;DR: The HLA Ligand Atlas as discussed by the authors is a collection of paired HLAI and HLA-II immunopeptidomes from 227 benign human tissue samples, which facilitates a balanced comparison between tumor and benign tissues on HLA ligand level.