R
Rui Moreira
Researcher at University of Lisbon
Publications - 240
Citations - 6062
Rui Moreira is an academic researcher from University of Lisbon. The author has contributed to research in topics: Plasmodium falciparum & Finite element method. The author has an hindex of 38, co-authored 229 publications receiving 4978 citations. Previous affiliations of Rui Moreira include Open University & University of Aveiro.
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Journal ArticleDOI
Primaquine revisited six decades after its discovery.
TL;DR: Presently, aablaquine and tafenoquine the two most promising primaquine analogues are already in the final stages of clinical trials against Plasmodium vivax and P. falciparum, a new hope against malaria and other primquine-sensitive illnesses, such as Pneumocystis Pneumonia or the Chagas disease.
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Towards the sustainable discovery and development of new antibiotics
Marcus Miethke,Marco Pieroni,Tilmann Weber,Mark Brönstrup,Peter Hammann,Ludovic Halby,Paola B. Arimondo,Philippe Glaser,Bertrand Aigle,Helge B. Bode,Helge B. Bode,Rui Moreira,Yanyan Li,Andriy Luzhetskyy,Marnix H. Medema,Jean-Luc Pernodet,Marc Stadler,José R. Tormo,Olga Genilloud,Andrew W. Truman,Kira J. Weissman,Eriko Takano,Stefano Sabatini,Evi Stegmann,Heike Brötz-Oesterhelt,Wolfgang Wohlleben,Myriam Seemann,Martin Empting,Anna K. H. Hirsch,Brigitta Loretz,Claus-Michael Lehr,Alexander Titz,Jennifer Herrmann,Timo Jaeger,Silke Alt,Thomas Hesterkamp,Mathias Winterhalter,Andrea Schiefer,Kenneth Pfarr,Achim Hoerauf,Heather Graz,Michael Graz,Mika Lindvall,Savithri Ramurthy,Anders Karlén,Maarten van Dongen,Hrvoje Petković,Andreas Keller,Frédéric Peyrane,Stefano Donadio,Laurent Fraisse,Laura J. V. Piddock,Ian H. Gilbert,Heinz E. Moser,Rolf Müller +54 more
TL;DR: In this paper, the authors present a strategic blueprint to substantially improve our ability to discover and develop new antibiotics, and propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding.
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Indoloquinolines as Scaffolds for Drug Discovery
TL;DR: An overview of the potential of indoloquinolines as scaffolds in drug discovery is presented by reviewing the in vitro and in vivo biological activities of natural and synthetic analogues, as well as the proposed mechanisms of action and structure-activity relationships.
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Synthetic organic chemistry driven by artificial intelligence
TL;DR: The underlying concepts of artificial intelligence are examined to demystify AI for bench chemists in order that they may embrace it as a tool rather than fear it as an competitor, spur future research by pinpointing the gaps in knowledge and delineate how chemical AI will run in the era of digital chemistry.
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Michael Acceptors as Cysteine Protease Inhibitors
Maria M. M. Santos,Rui Moreira +1 more
TL;DR: This review emphasizes on the new developments from literature reports on Michael acceptors as potential cysteine protease inhibitors, namely vinyl sulfones, alpha,beta-unsaturated carbonyl derivatives and aza-peptides.