C
Céline Cougoule
Researcher at University of Toulouse
Publications - 63
Citations - 1890
Céline Cougoule is an academic researcher from University of Toulouse. The author has contributed to research in topics: Medicine & Podosome. The author has an hindex of 22, co-authored 46 publications receiving 1380 citations. Previous affiliations of Céline Cougoule include National Scientific and Technical Research Council & Paul Sabatier University.
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Journal ArticleDOI
Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis.
Céline Cougoule,Céline Cougoule,Véronique Le Cabec,Véronique Le Cabec,Renaud Poincloux,Talal Al Saati,Jean-Louis Mege,Guillaume Tabouret,Guillaume Tabouret,Clifford A. Lowell,Nathalie Laviolette-Malirat,Nathalie Laviolette-Malirat,Isabelle Maridonneau-Parini,Isabelle Maridonneau-Parini +13 more
TL;DR: Spatial organization of podosomes as large rosettes, proteolytic degradation of extracellular matrix, and 3D migration appeared to be functionally linked and regulated by Hck in macrophages.
Journal ArticleDOI
Blood leukocytes and macrophages of various phenotypes have distinct abilities to form podosomes and to migrate in 3D environments
Céline Cougoule,Céline Cougoule,Emeline Van Goethem,Emeline Van Goethem,Véronique Le Cabec,Véronique Le Cabec,Fanny Lafouresse,Fanny Lafouresse,Fanny Lafouresse,Loïc Dupré,Loïc Dupré,Loïc Dupré,Vikram Mehraj,Jean-Louis Mege,Claire Lastrucci,Claire Lastrucci,Isabelle Maridonneau-Parini,Isabelle Maridonneau-Parini +17 more
TL;DR: It is concluded that whereas all leukocytes use the amoeboid mode to migrate through porous matrices, it is only certain macrophages that can adopt the mesenchymal mode that permits migration through dense matrices.
Journal ArticleDOI
The human macrophage mannose receptor is not a professional phagocytic receptor
Véronique Le Cabec,Laurent J. Emorine,Isabelle Toesca,Céline Cougoule,Isabelle Maridonneau-Parini +4 more
TL;DR: It is shown that MR is not a professional phagocytic receptor, as it does not possess the ability to promote particle ingestion in nonphagocytical cells on its own, and it is proposed that Mr. MR is a binding receptor, which requires a partner to triggerPhagocytosis in some specialized cells such as macrophages.
Journal ArticleDOI
Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16(+) monocyte population via the IL-10/STAT3 axis.
Claire Lastrucci,Claire Lastrucci,Alan Bénard,Alan Bénard,Luciana Balboa,Karine Pingris,Karine Pingris,Shanti Souriant,Shanti Souriant,Renaud Poincloux,Renaud Poincloux,Talal Al Saati,Voahangy Rasolofo,Pablo González-Montaner,Sandra Inwentarz,Eduardo José Moraña,Ivanela Kondova,Frank A. W. Verreck,María del Carmen Sasiain,Olivier Neyrolles,Olivier Neyrolles,Isabelle Maridonneau-Parini,Isabelle Maridonneau-Parini,Geanncarlo Lugo-Villarino,Geanncarlo Lugo-Villarino,Céline Cougoule,Céline Cougoule +26 more
TL;DR: It is demonstrated that human monocytes are predisposed to differentiate towards an anti-inflammatory (M2-like) macrophage activation program characterized by the CD16+CD163+MerTK+pSTAT3+ phenotype and functional properties such as enhanced protease-dependent motility, pathogen permissivity and immunomodulation.
Journal ArticleDOI
The Process of Macrophage Migration Promotes Matrix Metalloproteinase-Independent Invasion by Tumor Cells
Romain Guiet,Emeline Van Goethem,Emeline Van Goethem,Céline Cougoule,Céline Cougoule,Stéphanie Balor,Annie Valette,Talal Al Saati,Clifford A. Lowell,Véronique Le Cabec,Véronique Le Cabec,Isabelle Maridonneau-Parini,Isabelle Maridonneau-Parini +12 more
TL;DR: Macrophages can also contribute to the invasiveness of tumor cells by remodeling the extracellular matrix and by opening the way to exit the tumor and colonize the surrounding tissues in an MMP-dispensable manner.