R
Renaud Poincloux
Researcher at University of Toulouse
Publications - 61
Citations - 3989
Renaud Poincloux is an academic researcher from University of Toulouse. The author has contributed to research in topics: Podosome & Cytoskeleton. The author has an hindex of 27, co-authored 54 publications receiving 3414 citations. Previous affiliations of Renaud Poincloux include Centre national de la recherche scientifique & Paul Sabatier University.
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Journal ArticleDOI
Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia.
TL;DR: Current knowledge about MT1-MMP trafficking and its importance for the regulation of protease activity at invadopodia is reviewed and new insight is brought into mechanisms of cancer-cell invasion and reveals potential pharmacological targets.
Journal ArticleDOI
Matrix architecture dictates three-dimensional migration modes of human macrophages: differential involvement of proteases and podosome-like structures.
Emeline Van Goethem,Renaud Poincloux,Fabienne Gauffre,Isabelle Maridonneau-Parini,Véronique Le Cabec +4 more
TL;DR: It is shown that human macrophages also perform the mesenchymal mode but in a distinct manner than tumor cells, and they naturally adapt their migration mode to the environmental constraints.
Journal ArticleDOI
Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages
Hélène Botella,Hélène Botella,Pascale Peyron,Pascale Peyron,Florence Levillain,Florence Levillain,Renaud Poincloux,Renaud Poincloux,Yannick Poquet,Yannick Poquet,Irène Brandli,Irène Brandli,Irène Brandli,Chuan Wang,Chuan Wang,Chuan Wang,Ludovic Tailleux,Sylvain Tilleul,Guillaume M. Charrière,Guillaume M. Charrière,Simon J. Waddell,Maria Foti,Geanncarlo Lugo-Villarino,Geanncarlo Lugo-Villarino,Qian Gao,Isabelle Maridonneau-Parini,Isabelle Maridonneau-Parini,Philip D. Butcher,Paola Ricciardi Castagnoli,Brigitte Gicquel,Chantal de Chastellier,Chantal de Chastellier,Chantal de Chastellier,Olivier Neyrolles,Olivier Neyrolles +34 more
TL;DR: The use of P1-type ATPases represents a M. tuberculosis strategy to neutralize the toxic effects of zinc in macrophages, suggesting that heavy metal toxicity and its counteraction might represent yet another chapter in the host-microbe arms race.
Journal ArticleDOI
Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel
Renaud Poincloux,Olivier Collin,Floria Lizárraga,Maryse Romao,Marcel Debray,Matthieu Piel,Philippe Chavrier +6 more
TL;DR: Findings support a model whereby actomyosin-based uropod contractility generates traction forces on the β1 integrin adhesion system to drive cell propulsion within the 3D matrix, with no contribution of lamellipodia extension or blebbing to movement.
Journal ArticleDOI
MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7.
Anika Steffen,Anika Steffen,Gaëlle Le Dez,Gaëlle Le Dez,Renaud Poincloux,Renaud Poincloux,Chiara Recchi,Chiara Recchi,Pierre Nassoy,Pierre Nassoy,Klemens Rottner,Thierry Galli,Thierry Galli,Philippe Chavrier,Philippe Chavrier +14 more
TL;DR: In this paper, the authors showed that MT1-MMP-dependent matrix degradation at invadopodia is regulated by the v-SNARE TI-VAMP/VAMP7, hence providing the molecular inventory mediating focal degradative activity of cancer cells.