G
Geanncarlo Lugo-Villarino
Researcher at University of Toulouse
Publications - 63
Citations - 4061
Geanncarlo Lugo-Villarino is an academic researcher from University of Toulouse. The author has contributed to research in topics: Immune system & Mycobacterium tuberculosis. The author has an hindex of 26, co-authored 59 publications receiving 3328 citations. Previous affiliations of Geanncarlo Lugo-Villarino include University of California, San Diego & University of California, Los Angeles.
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Journal ArticleDOI
Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System
Wendy S. Garrett,Graham M. Lord,Graham M. Lord,Graham M. Lord,Shivesh Punit,Geanncarlo Lugo-Villarino,Sarkis K. Mazmanian,Susumu Ito,Jonathan N. Glickman,Laurie H. Glimcher +9 more
TL;DR: A profound and unexpected function for T-bet is described in influencing the behavior of host inflammatory activity and commensal bacteria and this colitis is communicable to genetically intact hosts.
Journal ArticleDOI
Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages
Hélène Botella,Hélène Botella,Pascale Peyron,Pascale Peyron,Florence Levillain,Florence Levillain,Renaud Poincloux,Renaud Poincloux,Yannick Poquet,Yannick Poquet,Irène Brandli,Irène Brandli,Irène Brandli,Chuan Wang,Chuan Wang,Chuan Wang,Ludovic Tailleux,Sylvain Tilleul,Guillaume M. Charrière,Guillaume M. Charrière,Simon J. Waddell,Maria Foti,Geanncarlo Lugo-Villarino,Geanncarlo Lugo-Villarino,Qian Gao,Isabelle Maridonneau-Parini,Isabelle Maridonneau-Parini,Philip D. Butcher,Paola Ricciardi Castagnoli,Brigitte Gicquel,Chantal de Chastellier,Chantal de Chastellier,Chantal de Chastellier,Olivier Neyrolles,Olivier Neyrolles +34 more
TL;DR: The use of P1-type ATPases represents a M. tuberculosis strategy to neutralize the toxic effects of zinc in macrophages, suggesting that heavy metal toxicity and its counteraction might represent yet another chapter in the host-microbe arms race.
Journal ArticleDOI
T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells
Geanncarlo Lugo-Villarino,Roberto Maldonado-López,Richard Possemato,Cristina Penaranda,Laurie H. Glimcher +4 more
TL;DR: The rapid up-regulation of T-bet by IFN-γ in DCs coupled with a function for DC-derived IFN -γ in T cell activation may constitute a positive feedback loop to maximize type 1 immunity.
Journal ArticleDOI
The role of the lung microbiota and the gut-lung axis in respiratory infectious diseases.
TL;DR: The beneficial role of the body's commensal bacteria during airway infectious diseases is highlighted, including recent evidence highlighting their local (lung) or distal (gut) contribution in this process.
Journal ArticleDOI
Identification of dendritic antigen-presenting cells in the zebrafish
Geanncarlo Lugo-Villarino,Keir M. Balla,David L. Stachura,Karina Bañuelos,Miriam B. F. Werneck,David Traver +5 more
TL;DR: These studies suggest that the cellular constituents responsible for antigen presentation are remarkably conserved from teleosts to mammals, and indicate that the zebrafish may serve as a unique model to study the origin of APC subsets and their evolutionary role as the link between the innate and adaptive immune systems.