C
Charles Antzelevitch
Researcher at Lankenau Institute for Medical Research
Publications - 527
Citations - 58069
Charles Antzelevitch is an academic researcher from Lankenau Institute for Medical Research. The author has contributed to research in topics: Brugada syndrome & Repolarization. The author has an hindex of 118, co-authored 515 publications receiving 54661 citations. Previous affiliations of Charles Antzelevitch include University of Southern California & Main Line Health.
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The J Wave Syndromes and Their Role in Sudden Cardiac Death
TL;DR: Current knowledge about J-wave syndromes is summarized by linking bench work with the bedside, indicating that J wave abnormalities, which are often accompanied by early repolarization and ST segment elevation on the ECG, are in some cases associated with a risk of sudden cardiac death.
The Characteristics of Modulated Parasystole Under Conditions of Constant and Variable Heart Rate: A Mathematical Model
TL;DR: The results indicate that physiologically relevant variability of heart rate can result in electrocardiographic patterns of modulated parasystole in which entrainment of the ectopic pacemaker by the sinus rhythm is not as readily apparent.
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Effect of autonomic influences to induce triggered activity in muscular sleeves extending into the coronary sinus of the canine heart and its suppression by ranolazine.
TL;DR: The current study was designed to extend the existing knowledge of the electrophysiological and pharmacologic properties of canine CS preparations and assess their response to inhibition of late INa following autonomic stimulation.
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Common variants in SCN10A gene associated with Brugada syndrome.
TL;DR: In this paper, the role of SCN10A common variants in Brugada syndrome (BrS) was investigated in 197 patients with SCN5A-SCN10a co-transfected TSA201 cells.
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Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for KCND3-Encoded Kv4.3 Gain-of-Function-Associated J-Wave Syndromes
Dan Ye,Wei Zhou,Samantha K. Hamrick,David Lester,CS John Kim,Hector Barajas-Martinez,Dan Hu,John R. Giudicessi,Charles Antzelevitch,Michael J. Ackerman +9 more
TL;DR: This preclinical study provides pharmacological and functional evidence to suggest that Acacetin may be a novel therapeutic for patients with KCND3 gain-of-function-associated J wave syndrome by inhibiting Ito and abolishing the accentuated action potential notch in patient-derived iPSC-CMs.