C
Charles Antzelevitch
Researcher at Lankenau Institute for Medical Research
Publications - 527
Citations - 58069
Charles Antzelevitch is an academic researcher from Lankenau Institute for Medical Research. The author has contributed to research in topics: Brugada syndrome & Repolarization. The author has an hindex of 118, co-authored 515 publications receiving 54661 citations. Previous affiliations of Charles Antzelevitch include University of Southern California & Main Line Health.
Papers
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Book ChapterDOI
Ionic and Cellular Mechanisms Underlying J Wave Syndromes
TL;DR: The objective in this chapter is to provide an integrated review of the clinical characteristics, risk stratifiers, as well as the molecular, ionic, cellular and genetic mechanisms underlying the J wave syndromes.
Journal ArticleDOI
Call "the Cleaners": How to Treat Drug-Induced Torsades de Pointes.
TL;DR: A drug-induced torsades de pointes (TDP) is the epitome of a therapeutic intervention that goes awry despite the best intentions as discussed by the authors, often involving medications that have no cardiac indications and are therefore assumed to be free of cardiac effects.
Patent
Loss of function mutations in calcium channel polypeptides associated with sudden cardiac death
TL;DR: In this paper, previously unknown mutations of the CACNA1C and CACNB2b genes are disclosed which are involved in ion channel disruptions associated with shorter than normal QT interval and ST segment elevation syndrome.
Book ChapterDOI
Cellular, Molecular, and Pharmacologic Mechanisms Underlying Drug-Induced Cardiac Arrhythmogenesis
TL;DR: Pharmacologic agents can contribute to cardiac arrhythmogenesis by altering conduction, repolarization, or automaticity, and by inducing triggered activity in the form of early or delayed afterdepolarizations.
Journal ArticleDOI
Frequency of Irritable Bowel Syndrome in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern.
Anil S. Sarica,Serhat Bor,Mehmet Orman,Hector Barajas-Martinez,Jyh-Ming Jimmy Juang,Charles Antzelevitch,Can Hasdemir +6 more
TL;DR: In this article, the authors examined the hypothesis that these two inherited syndromes are linked and identified 8 putative SCN5A/SCN1B variants in 7 (12.3%) patients with BrS/DI-type 1 Brugada pattern (DI-Type 1 BrP) and 1 (3.2%) patient in control group.