C
Charles Antzelevitch
Researcher at Lankenau Institute for Medical Research
Publications - 527
Citations - 58069
Charles Antzelevitch is an academic researcher from Lankenau Institute for Medical Research. The author has contributed to research in topics: Brugada syndrome & Repolarization. The author has an hindex of 118, co-authored 515 publications receiving 54661 citations. Previous affiliations of Charles Antzelevitch include University of Southern California & Main Line Health.
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Journal ArticleDOI
Fever and Brugada syndrome
TL;DR: The characteristics of the Brugada Syndrome are similar to those reported by Nademanee et al. for patients with sudden unexpected death syndrome (SUDS) and a recent study has advanced data suggesting the two syndromes are genetically and functionally the same disorder.
Book ChapterDOI
The Role of Late I Na in Development of Cardiac Arrhythmias
Charles Antzelevitch,Vladislav V. Nesterenko,John C. Shryock,Sridharan Rajamani,Yejia Song,Luiz Belardinelli +5 more
TL;DR: Many local anesthetic and antiarrhythmic agents have a higher potency to block late I Na as compared with fast I Na, and several novel compounds appear to be the most selective inhibitors of cardiacLate I Na reported to date.
Journal ArticleDOI
Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias.
Tengxian Liu,Barry S. Brown,Ying Wu,Charles Antzelevitch,Peter R. Kowey,Peter R. Kowey,Gan-Xin Yan,Gan-Xin Yan +7 more
TL;DR: This study provides a blinded evaluation of the isolated arterially-perfused rabbit wedge preparation demonstrating both a high sensitivity and specificity in the assessment of 13 agents with varying propensity for causing TdP.
Journal ArticleDOI
Electrophysiologic properties and antiarrhythmic actions of a novel antianginal agent.
Charles Antzelevitch,Luiz Belardinelli,Wu L,Fraser H,Andrew C. Zygmunt,Alexander Burashnikov,Di Diego Jm,Jeffrey M. Fish,Jonathan M. Cordeiro,Robert J. Goodrow,Fabiana S. Scornik,Guillermo J. Pérez +11 more
TL;DR: Ranolazine's actions to reduce TDR and suppress early afterdepolarization suggest that in addition to its anti-anginal actions, the drug possesses antiarrhythmic activity.
Journal ArticleDOI
Gain of function in IKs secondary to a mutation in KCNE5 associated with atrial fibrillation
Lasse Steen Ravn,Yoshiyasu Aizawa,Guido D. Pollevick,Jacob Hofman-Bang,Jacob Hofman-Bang,Jonathan M. Cordeiro,Ulrik Dixen,Gorm B. Jensen,Yuesheng Wu,Elena Burashnikov,Stig Haunsø,Stig Haunsø,Alejandra Guerchicoff,Dan Hu,Jesper Hastrup Svendsen,Jesper Hastrup Svendsen,Michael Christiansen,Michael Christiansen,Charles Antzelevitch +18 more
TL;DR: The results of this study suggest that a missense mutation in KCNE5 may be associated with nonfamilial or acquired forms of AF, and the arrhythmogenic mechanism most likely is a gain of function of IKs.