C
Charles Antzelevitch
Researcher at Lankenau Institute for Medical Research
Publications - 527
Citations - 58069
Charles Antzelevitch is an academic researcher from Lankenau Institute for Medical Research. The author has contributed to research in topics: Brugada syndrome & Repolarization. The author has an hindex of 118, co-authored 515 publications receiving 54661 citations. Previous affiliations of Charles Antzelevitch include University of Southern California & Main Line Health.
Papers
More filters
Journal ArticleDOI
Differences in the electrophysiological response of canine ventricular epicardium and endocardium to ischemia. Role of the transient outward current.
Anton Lukas,Charles Antzelevitch +1 more
TL;DR: Results were obtained in tissues and myocytes obtained from the same myocardial layers, suggesting that the differential sensitivities of epicardium and endocardium to ischemia are largely a result of inherent differences in cellular properties.
Journal ArticleDOI
Overview of Basic Mechanisms of Cardiac Arrhythmia.
TL;DR: A cardiac arrhythmia simply defined is a variation from the normal heart rate and/or rhythm that is not physiologically justified.
Journal ArticleDOI
I(to) and action potential notch are smaller in left vs. right canine ventricular epicardium
TL;DR: The data point to prominent differences in the magnitude of the I(to) 1-mediated action potential notch in cells at the surface of RVE compared with the LVE and suggest that important distinctions may exist in the response of these two tissues to pharmacological agents and pathophysiological states.
Journal ArticleDOI
Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle.
Andrew C. Zygmunt,Geoffrey T. Eddlestone,George P. Thomas,Vladislav V. Nesterenko,Charles Antzelevitch +4 more
TL;DR: It is concluded that a larger late sodium conductance in midmyocardial cells will favor longer action potentials in these cells, and drugs that slow inactivation of sodium channels will produce a nonuniform response across the ventricular wall that is proarrhythmic.
Journal ArticleDOI
Does Tpeak–Tend provide an index of transmural dispersion of repolarization?
Charles Antzelevitch,Serge Sicouri,José M. Di Diego,Alexander Burashnikov,Sami Viskin,Wataru Shimizu,Gan-Xin Yan,Peter R. Kowey,Li Zhang +8 more
TL;DR: Tpeak-Tend is more valuable than QTc and QT dispersion as a predictor of TdP in patients with acquired LQTS and changes in this parameter are thought to be capable of reflecting changes in spatial dispersion of repolarization, particularly TDR, and thus may be prognostic of arrhythmic risk under a variety of conditions.