C
Charles David James
Researcher at Northwestern University
Publications - 36
Citations - 1293
Charles David James is an academic researcher from Northwestern University. The author has contributed to research in topics: Glioma & In vivo. The author has an hindex of 14, co-authored 36 publications receiving 804 citations. Previous affiliations of Charles David James include University of California & University of California, San Francisco.
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Journal ArticleDOI
An overview of meningiomas.
Robin A. Buerki,Craig Horbinski,Tim J. Kruser,Peleg M. Horowitz,Charles David James,Rimas V. Lukas +5 more
TL;DR: This review will cover the histo- and molecular pathology of meningiomas, including recent 2016 updates to the WHO classification of CNS tumors, and discuss clinical and radiographic presentation and therapeutic management.
Journal ArticleDOI
Immunocompetent murine models for the study of glioblastoma immunotherapy
Taemin Oh,Shayan Fakurnejad,Eli T. Sayegh,Aaron J. Clark,Michael E. Ivan,Matthew Z. Sun,Michael Safaee,Orin Bloch,Charles David James,Andrew T. Parsa +9 more
TL;DR: Five contemporary immunocompetent mouse models are reviewed, each of which offer a suitable platform for testing novel immunotherapeutic approaches for glioblastoma patients.
Journal ArticleDOI
MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma
Tianzhi Huang,Chung Kwon Kim,Chung Kwon Kim,Angel Alvarez,Rajendra P. Pangeni,Rajendra P. Pangeni,Xuechao Wan,Xiao Song,Taiping Shi,Yongyong Yang,Namratha Sastry,Craig Horbinski,Songjian Lu,Roger Stupp,John A. Kessler,Ryo Nishikawa,Ichiro Nakano,Erik P. Sulman,Xinghua Lu,Charles David James,Xiao Ming Yin,Bo Hu,Shi Yuan Cheng +22 more
TL;DR: In this paper, the authors identify ATG4B as a substrate of mammalian sterile20-like kinase (STK) 26/MST4, which stimulates autophagocyte activity and increases autophagic flux.
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Infiltrating T Cells Increase IDO1 Expression in Glioblastoma and Contribute to Decreased Patient Survival.
Lijie Zhai,Erik Ladomersky,Kristen L. Lauing,Meijing Wu,Matthew Genet,Galina Gritsina,Balázs Győrffy,Priscilla K. Brastianos,David C. Binder,Jeffrey A. Sosman,Francis J. Giles,Charles David James,Craig Horbinski,Roger Stupp,Derek A. Wainwright +14 more
TL;DR: It is demonstrated that high intratumoral IDO1 mRNA levels correlate with a poor GBM patient prognosis and that future efforts aimed at increasing T-cell–mediated effects against GBM should consider combinatorial approaches that coinhibit potential T- cell–mediated IDO 1 enhancement during therapy.
Journal ArticleDOI
Molecular and translational advances in meningiomas.
Suganth Suppiah,Farshad Nassiri,Wenya Linda Bi,Ian F. Dunn,Clemens Oliver Hanemann,Craig Horbinski,Rintaro Hashizume,Charles David James,Christian Mawrin,Houtan Noushmehr,Arie Perry,Felix Sahm,Andrew E. Sloan,Andreas von Deimling,Patrick Y. Wen,Kenneth Aldape,Gelareh Zadeh +16 more
TL;DR: The most up-to-date knowledge of molecular alterations that provide insight into meningioma behavior and are ready for application to clinical trial investigation are reviewed, and the landscape of available preclinical models in meningingiomas is highlighted.