C
Charles E. Wade
Researcher at University of Texas Health Science Center at Houston
Publications - 609
Citations - 40501
Charles E. Wade is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Resuscitation & Injury Severity Score. The author has an hindex of 90, co-authored 579 publications receiving 36280 citations. Previous affiliations of Charles E. Wade include University of California, Davis & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Transfusion of plasma, platelets, and red blood cells in a 1: 1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: The PROPPR randomized clinical trial
John B. Holcomb,Barbara C. Tilley,Sarah Baraniuk,Erin E. Fox,Charles E. Wade,Jeanette M. Podbielski,Deborah J. del Junco,Karen J. Brasel,Karen J. Brasel,Eileen M. Bulger,Rachael A. Callcut,Mitchell J. Cohen,Bryan A. Cotton,Timothy C. Fabian,Kenji Inaba,Jeffrey D. Kerby,Peter Muskat,Peter Muskat,Terence O'Keeffe,Sandro Rizoli,Bryce R.H. Robinson,Thomas M. Scalea,Martin A. Schreiber,Deborah M. Stein,Jordan A. Weinberg,Jeannie Callum,John R. Hess,Nena Matijevic,Christopher N. Miller,Jean-Francois Pittet,David B. Hoyt,Gail D. Pearson,Brian G. Leroux,Gerald van Belle +33 more
TL;DR: In this article, the effectiveness and safety of transfusing patients with severe trauma and major bleeding using plasma, platelets, and red blood cells in a 1:1:1 ratio compared with a 1 :1:2 ratio was evaluated.
Journal ArticleDOI
Death on the battlefield (2001-2011): Implications for the future of combat casualty care
Brian J. Eastridge,Robert L. Mabry,Peter Seguin,Joyce Cantrell,Terrill Tops,Paul Uribe,Olga Mallett,Tamara Zubko,Lynne Oetjen-Gerdes,Todd E. Rasmussen,Frank K. Butler,Russ S Kotwal,John B. Holcomb,Charles E. Wade,Howard R. Champion,Mimi Lawnick,Leon E. Moores,Lorne H. Blackbourne +17 more
TL;DR: To significantly impact the outcome of combat casualties with PS injury, strategies must be developed to mitigate hemorrhage and optimize airway management or reduce the time interval between the battlefield point of injury and surgical intervention.
Journal ArticleDOI
The Ratio of Blood Products Transfused Affects Mortality in Patients Receiving Massive Transfusions at a Combat Support Hospital
Matthew A. Borgman,Philip C. Spinella,Jeremy G. Perkins,Kurt W. Grathwohl,Thomas Repine,Alec C. Beekley,James A. Sebesta,Donald H. Jenkins,Charles E. Wade,John B. Holcomb +9 more
TL;DR: In patients with combat-related trauma requiring massive transfusion, a high 1:1.4 plasma to RBC ratio is independently associated with improved survival to hospital discharge, primarily by decreasing death from hemorrhage.
Journal ArticleDOI
Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations.
TL;DR: Improvements in early hemorrhage control and resuscitation and the prevention and aggressive treatment of coagulopathy appear to have the greatest potential to improve outcomes in severely injured trauma patients.
Journal ArticleDOI
Damage control resuscitation: Directly addressing the early coagulopathy of trauma
John B. Holcomb,Donald H. Jenkins,Peter Rhee,Jay A. Johannigman,Peter F. Mahoney,Sumeru G. Mehta,E. Darrin Cox,Michael J. Gehrke,Gregory J. Beilman,Martin A. Schreiber,Stephen F. Flaherty,Kurt W. Grathwohl,Phillip C. Spinella,Jeremy G. Perkins,Alec C. Beekley,Neil R. McMullin,Myung S. Park,Ernest A. Gonzalez,Charles E. Wade,Michael A. Dubick,C. William Schwab,Frederick A. Moore,Howard R. Champion,David B. Hoyt,John R. Hess +24 more
TL;DR: Reports of lactated Ringer s solution and normal saline increasing reperfusion injury and leukocyte adhesion lead one to conclude that the standard crystalloid based resuscitation guidelines in pre hospital trauma life support (PHTLS) and advanced traumaLife support (ATLS) may worsen the presenting acidosis and coagulopathy in severely injured trauma patients, and possibly increase ARDS, SIRS, and MOF.