C
Charles Y. Lin
Researcher at Baylor College of Medicine
Publications - 128
Citations - 19573
Charles Y. Lin is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Transcription factor & Enhancer. The author has an hindex of 42, co-authored 116 publications receiving 15889 citations. Previous affiliations of Charles Y. Lin include Harvard University & University of California, San Diego.
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Journal ArticleDOI
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Warren A. Whyte,David A. Orlando,Denes Hnisz,Brian J. Abraham,Charles Y. Lin,Charles Y. Lin,Michael H. Kagey,Peter B. Rahl,Tong Ihn Lee,Richard A. Young +9 more
TL;DR: In this article, the ESC master transcription factors form unusual enhancer domains at most genes that control the pluripotent state, called super-enhancers, which consist of clusters of enhancers that are densely occupied by the master regulators and Mediator.
Journal ArticleDOI
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
Jakob Lovén,Heather A. Hoke,Charles Y. Lin,Charles Y. Lin,Ashley Lau,David A. Orlando,Christopher R. Vakoc,James E. Bradner,Tong Ihn Lee,Richard A. Young +9 more
TL;DR: This work investigates how inhibition of the widely expressed transcriptional coactivator BRD4 leads to selective inhibition ofThe MYC oncogene in multiple myeloma (MM), and finds that super-enhancers were found at key oncogenic drivers in many other tumor cells.
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Warren A. Whyte,David A. Orlando,Denes Hnisz,Brian J. Abraham,Charles Y. Lin,Charles Y. Lin,Michael H. Kagey,Peter B. Rahl,Tong Ihn Lee,Richard A. Young +9 more
TL;DR: It is reported here that the ESC master transcription factors form unusual enhancer domains at most genes that control the pluripotent state, which consist of clusters of enhancers that are densely occupied by the master regulators and Mediator.
Journal ArticleDOI
Transcriptional Amplification in Tumor Cells with Elevated c-Myc
Charles Y. Lin,Jakob Lovén,Peter B. Rahl,Ronald M. Paranal,Christopher B. Burge,James E. Bradner,Tong Ihn Lee,Richard A. Young +7 more
TL;DR: It is reported here that in tumor cells expressing high levels of c-Myc the transcription factor accumulates in the promoter regions of active genes and causes transcriptional amplification, producing increased levels of transcripts within the cell's gene expression program.
Journal ArticleDOI
c-Myc regulates transcriptional pause release.
Peter B. Rahl,Charles Y. Lin,Amy C. Seila,Ryan A. Flynn,Scott McCuine,Christopher B. Burge,Phillip A. Sharp,Richard A. Young +7 more
TL;DR: It is reported that promoter-proximal pausing is a general feature of transcription by Pol II in mammalian cells and thus an additional step where regulation of gene expression occurs, and that the transcription factor c-Myc, a key regulator of cellular proliferation, plays a major role in Pol II pause release.