Charles Y. Lin

TL;DR: In this paper, a hybrid Monte Carlo/MD (MC/MD) method was proposed to accelerate the equilibration of water between buried cavities and the surrounding solvent, while sampling from the thermodynamically correct distribution of states.

TL;DR: In this article, the Apoa1 locus was identified and validated as a novel integration site that supports durable transgene expression in the liver for gene therapy applications, and the endogenous apoa1 promoter can drive robust and sustained expression of therapeutic proteins, such as apolipoprotein E (APOE), dramatically reducing plasma lipids in a model of hypercholesterolemia.

TL;DR: CorenODE as discussed by the authors is a computational algorithm for genome-wide transcription network decomposition that identifies the transcription factors (TFs) IRF8 and MEF2C as positive regulators and MYB and MEIS1 as negative regulators of MHC-II expression in AML cells.

TL;DR: The microanantomy of the LSC niche is investigated hypothesizing that it may differ from the normal HSPC niche, and it is shown that BCR-ABL1 + Lin – c-Kit + Sca-1 + (LKS) CD150 + CD48 – (L KS SLAM) cells, which harbor the L SC fraction in the CML model, homed to locations further away from the endosteum than their normal counterparts.

TL;DR: Critical mechanistic insight is provided into KLF15 function and a hepatocyte-intrinsic transcriptional module that potently regulates systemic corticosteroid transport and inflammation is identified.