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Charles Y. Lin
Researcher at Baylor College of Medicine
Publications - 128
Citations - 19573
Charles Y. Lin is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Transcription factor & Enhancer. The author has an hindex of 42, co-authored 116 publications receiving 15889 citations. Previous affiliations of Charles Y. Lin include Harvard University & University of California, San Diego.
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Journal ArticleDOI
Models of human core transcriptional regulatory circuitries
Violaine Saint-André,Alexander J. Federation,Charles Y. Lin,Brian J. Abraham,Jessica Reddy,Tong Ihn Lee,James E. Bradner,Richard A. Young +7 more
TL;DR: This work uses super-enhancer maps to generate CRC models for 75 human cell and tissue types and these core circuitry models should prove valuable for further investigating cell-type-specific transcriptional regulation in healthy and diseased cells.
Journal ArticleDOI
In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.
Luke W. Koblan,Luke W. Koblan,Luke W. Koblan,Michael R. Erdos,Christine D. Wilson,Christine D. Wilson,Christine D. Wilson,Wayne A. Cabral,Jonathan M. Levy,Jonathan M. Levy,Jonathan M. Levy,Zheng-Mei Xiong,Urraca Tavarez,Lindsay M. Davison,Yantenew G. Gete,Xiaojing Mao,Gregory A. Newby,Gregory A. Newby,Gregory A. Newby,Sean P. Doherty,Narisu Narisu,Quanhu Sheng,Chad Krilow,Charles Y. Lin,Leslie B. Gordon,Leslie B. Gordon,Kan Cao,Francis S. Collins,Jonathan D. Brown,David R. Liu,David R. Liu,David R. Liu +31 more
TL;DR: In this article, Adenine base editors (ABEs) were used to correct the pathogenic HGPS mutation in cultured fibroblasts derived from children with progeria and in a mouse model of HGPS.
Journal ArticleDOI
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer.
Holger Heyn,Enrique Vidal,Humberto J. Ferreira,Miguel Vizoso,Sergi Sayols,Antonio Gomez,Sebastian Moran,Raquel Boque-Sastre,Sonia Guil,Anna Martínez-Cardús,Charles Y. Lin,Charles Y. Lin,Romina Royo,Jose V. Sanchez-Mut,Ramon Martinez,Marta Gut,David Torrents,David Torrents,Modesto Orozco,Modesto Orozco,Ivo Gut,Richard A. Young,Manel Esteller,Manel Esteller +23 more
TL;DR: In this paper, the authors used bisulfite sequencing to examine uncharted regions of the epigenome and identify a type of far-reaching DNA methylation alteration in cancer cells of the distal regulatory sequences described as super-enhancers.
Journal ArticleDOI
Mutant NPM1 Maintains the Leukemic State through HOX Expression.
Lorenzo Brunetti,Michael C. Gundry,Daniele Sorcini,Anna Guzman,Yung-Hsin Huang,Raghav Ramabadran,Ilaria Gionfriddo,Federica Mezzasoma,Francesca Milano,Behnam Nabet,Dennis L. Buckley,Steven M. Kornblau,Charles Y. Lin,Paolo Sportoletti,Maria Paola Martelli,Brunangelo Falini,Margaret A. Goodell +16 more
TL;DR: It is shown that loss of NPM1c from the cytoplasm, either through nuclear relocalization or targeted degradation, results in immediate downregulation of homeobox genes followed by differentiation of AML cells, and prolongs survival of Npm1-mutated leukemic mice.
c-Myc regulates transcriptional pause release
Peter B. Rahl,Charles Y. Lin,Amy C. Seila,Ryan A. Flynn,Scott McCuine,Christopher B. Burge,Phillip A. Sharp,Richard A. Young +7 more
TL;DR: In this article, it was shown that the transcription factor c-Myc plays a major role in Pol II pause release rather than recruitment at its target genes, which suggests that some transcription factors recruit the transcription apparatus to promoters, whereas others effect promoter-proximal pause release.