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Charlie D. Chen
Researcher at Laboratory of Molecular Biology
Publications - 43
Citations - 5965
Charlie D. Chen is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Demethylase & Histone. The author has an hindex of 18, co-authored 39 publications receiving 5487 citations. Previous affiliations of Charlie D. Chen include Chinese Academy of Sciences & University of California, Los Angeles.
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Journal ArticleDOI
Molecular determinants of resistance to antiandrogen therapy
Charlie D. Chen,Derek S. Welsbie,Chris Tran,Sung Hee Baek,Randy Chen,Robert L. Vessella,Michael G. Rosenfeld,Charles L. Sawyers +7 more
TL;DR: Using microarray-based profiling of isogenic prostate cancer xenograft models, it is found that a modest increase in androgen receptor mRNA was the only change consistently associated with the development of resistance to antiandrogen therapy.
Journal ArticleDOI
Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
Chris Tran,Samedy Ouk,Nicola J. Clegg,Yu Chen,Philip A. Watson,Vivek K. Arora,John Wongvipat,Peter Smith-Jones,Dongwon Yoo,Andrew Kwon,Teresa Wasielewska,Derek S. Welsbie,Charlie D. Chen,Celestia S. Higano,Tomasz M. Beer,David T. Hung,Howard I. Scher,Michael E. Jung,Charles L. Sawyers +18 more
TL;DR: The diarylthiohydantoins RD162 and MDV3100 are characterized, two compounds optimized from a screen for nonsteroidal antiandrogens that retain activity in the setting of increased androgen receptor expression that appear to be promising candidates for treatment of advanced prostate cancer.
Journal ArticleDOI
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer
Yang Xiang,Ziqi Zhu,Gang Han,Xiaolei Ye,Bo Xu,Zhouchun Peng,Yuanjun Ma,Yi Yu,Hanqing Lin,Adele Pin Chen,Charlie D. Chen +10 more
TL;DR: JARID1B is identified as a demethylase capable of removing three methyl groups from histone H3 lysine 4 and up-regulated in prostate cancer and associates with androgen receptor and regulates its transcriptional activity.
Journal ArticleDOI
JMJD3 is a histone H3K27 demethylase.
TL;DR: JMJD3 is identified as a demethylase capable of removing the trimethyl group from histone H3 lysine 27 and upregulated in prostate cancer and its expression is higher in metastatic prostate cancer.
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Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer
Ruty Mehrian-Shai,Charlie D. Chen,T. Shi,Steve Horvath,Stanley F. Nelson,Juergen K. V. Reichardt,Charles L. Sawyers +6 more
TL;DR: It is established that PTEN and IGF BP-2 expression are inversely correlated in human brain and prostate cancers and implicate serum IGFBP-2 levels as a potential serum biomarker of PTEN status and PI3K Akt pathway activation in cancer patients.