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Charlotte M. McKee
Researcher at Vertex Pharmaceuticals
Publications - 11
Citations - 4410
Charlotte M. McKee is an academic researcher from Vertex Pharmaceuticals. The author has contributed to research in topics: Ivacaftor & Lumacaftor. The author has an hindex of 9, co-authored 11 publications receiving 2815 citations.
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Journal ArticleDOI
VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
Jane C. Davies,Samuel M. Moskowitz,Cynthia A. Brown,Alex Horsley,Marcus A. Mall,Edward F. McKone,Barry J. Plant,Dario Prais,Bonnie W. Ramsey,Jennifer L. Taylor-Cousar,Elizabeth Tullis,Ahmet Uluer,Charlotte M. McKee,Sarah A. Robertson,Rebecca A. Shilling,Christopher Simard,Fredrick Van Goor,David Waltz,Fengjuan Xuan,Young Tomothy John,Steven M. Rowe +20 more
TL;DR: Robust in vitro activity of VX‐659–tezacaftor–ivacaftor targeting P he508del CFTR protein translated into improvements for patients with Phe508del–MF or Phe484del–Phe50del genotypes.
Journal ArticleDOI
Ivacaftor treatment of cystic fibrosis in children aged 12 to <24 months and with a CFTR gating mutation (ARRIVAL): a phase 3 single-arm study
Margaret Rosenfeld,Claire E. Wainwright,Mark Higgins,Linda T Wang,Charlotte M. McKee,Daniel Campbell,S. Tian,Jennifer Schneider,Steve Cunningham,Jane C. Davies,William T. Harris,Peter J. Mogayzel,Karen McCoy,Carlos Milla,Ronald C. Rubenstein,Seth Walker,Philip Black,Gregory Montgomery,Susanna A. McColley,Peter Hiatt,Gregory S. Sawicki,Michael G. Rock,Paul Aurora,Felix Ratjen,Anirban Maitra,Andrew Ives,Erol A. Gaillard,Paul McNalley,Hiranjan Selvadurai,Philip Robinson +29 more
TL;DR: Ivacaftor was generally safe and well tolerated in children aged 12 to <24 months for up to 24 weeks and was associated with rapid and sustained reductions in sweat chloride concentrations.
Journal ArticleDOI
Clinical development of triple-combination CFTR modulators for cystic fibrosis patients with one or two F508del alleles.
Jennifer L. Taylor-Cousar,Marcus A. Mall,Bonnie W. Ramsey,Edward F. McKone,Elizabeth Tullis,Gautham Marigowda,Charlotte M. McKee,David Waltz,Samuel M. Moskowitz,Jessica H. Savage,Fengjuan Xuan,Steven M. Rowe +11 more
TL;DR: Next-generation CFTR correctors VX-659 and Vx-445, each in triple combination with tezacaftor and ivacaftor, improve CFTR processing, trafficking and function in vitro and have demonstrated clinical improvements in phase 2 studies in patients with CF with one or two F508del-CFTR alleles.
Journal ArticleDOI
Abstracts from the 23rd Italian congress of Cystic Fibrosis and the 13th National congress of Cystic Fibrosis Italian Society
Annamaria Bevivino,Alessandra Coiana,Annalisa Fogazzi,Fabiana Timelli,Sandra Signorini,Marco Lucarelli,Patrizia Morelli,Rita Padoan,Barbara Giordani,Annalisa Amato,Fabio Majo,Gianluca Ferrari,Serena Quattrucci,Laura Minicucci,Giovanna Floridia,Gianna Puppo Fornaro,Domenica Taruscio,Marco Salvatore,Manuela Seia,Silvia Pierandrei,Giovanna Blaconà,Valentina Salvati,Giovanni Sette,Giuseppe Cimino,Federica Sangiuolo,Adriana Eramo,Mirella Collura,Elisa Parisi,Annalisa Ferlisi,Gabriella Traverso,Marcella Bertolino,Lisa Termini,Maria A. Orlando,Caterina Di Girgenti,Valeria Pavone,Maria A. Calamia,Maria G. Silvestro,Caterina Lo Piparo,Francesca Ficili,Carla Colombo,Elizabeth Tullis,Jane C. Davies,Charlotte M. McKee,C DeSouza,David Waltz,Jessica H. Savage,Marc Fisher,Rebecca A. Shilling,Sam Moskowitz,Sarah Robertson,S. Tian,Jennifer L. Taylor-Cousar,Steven M. Rowe,Elisa Beccia,Elisa Beccia,Annalucia Carbone,Maria Favia,Stefano Castellani,Antonella Angiolillo,Valeria Casavola,Massimo Conese,Bruno Mario Cesana,Diego Falchetti,Fiorella Battistini,Elisabetta Bignamini,Cesare Braggion,Natalia Cirilli,Maria C. Lucanto,Vincenzina Lucidi,Antonio Manca,Valeria Raia,Novella Rotolo,D. Salvatore,Sonia Volpi,Erica Nazzari,Riccardo Guarise,Palmiro Mileto,F. Garbarino,Gianfranco Alicandro,Alberto Battezzati,Antonella Miriam Di Lullo,Marika Comegna,Felice Amato,Paola Iacotucci,Vincenzo Carnovale,Elena Cantone,Maurizio Iengo,Giuseppe Castaldo,Claudio Orlando,A. Casale,Angela Sepe,Fabiola De Gregorio,Antonia De Matteo,Alice Castaldo,Chiara Cimbalo,Antonella Tosco,Daniela Savi,Daniela Savi,Michela Mordenti,Enea Bonci,Patrizia Troiani,V. D'Alù,Paolo Rossi,Monica Varchetta,T. Perelli,S. Bertasi,Paolo Palange,Lucia Tardino,Giuseppe Fabio Parisi,Anna Portale,Chiara Franzonello,Maria Papale,Salvatore Leonardi,Francesca Pennisi,Sabina Maria Bruno,Giulia Licciardello,Giampiero Ferraguti,Manuela Sterrantino,Giancarlo Testino,Roberto Buzzetti,Cecilia Surace,Valentina M. Sofia,Nicola Ullmann,Antonio Novelli,Adriano Angioni,Renato Liguori,Francesca Manzoni,Chiara Di Palma,Sabrina Maietta,Federica Zarrilli,Vito Terlizzi,F. Alghisi,Giuseppe Tuccio,Valentina Tradati,Eliana di Stefano,Patrizia Dato,Maria G. Sciarrabone,Carmela Fondacaro,Federico Cresta,Valentina Baglioni,Silvia Garuti,Isabella Buffoni,Francesca Landi,Rosaria Casciaro,Daniela Girelli,Antonio Teri,Samantha Sottotetti,A. Biffi,Chiara Vignati,M. D'Accico,Anna Maraschini,M. Arghittu,Giovanna Pizzamiglio,Elisa Cariani,Daniela Dolce,Novella Ravenni,Silvia Campana,Erica Camera,Carlo Castellani,Giovanni Taccetti,Eleonora Calderone,Roberto Bandettini,Chiara Degli Innocenti,Chiara Castellani,Eleonora Masi,Maria Chiara Cavicchi,Beatrice Ferrari,Ramona Pezzotta,Piercarlo Poli,Serena Messali,Silvana Timpano,Erika Scaltriti,Stefano Pongolini,Simona Fiorentini,Silvia Bresci,Lorenzo Corsi,Beatrice Borchi,Annalisa Cavallo,Filippo Bartalesi,Massimo Pistolesi,Alessandro Bartoloni,Federica Arcoleo,Tiziana Pensabene,Giovanni Bacci,Federica Armanini,Ersilia Fiscarelli,Nicola Segata,Alessio Mengoni,Maria V. Di Toppa,Nicoleta Popa,Francesco Felicetti,Sonia Graziano,Riccardo Ciprandi,Rita Pescini,Guendalina Graffigna,Serena Barello,P. Catastini,Salvatore De Masi,C. Braggion,Lucia Guarnuto,Emanuela Di Liberti,Valentina Patti,Massimo Luca Castellazzi,Valeria Daccò,L. Claut,Matteo Giuliari,Luana Vicentini,Fausto Tilotta,Antonella Paciaroni,Sabino Della Sala,Cristina Guerzoni,Elisa Andreatta,Grazia Dinnella,Orazia Maria Granata,Tommaso Silvano Aronica,Mimì Crapisi,Donatella Fogazza,Luca Alessi,Flavia Mulè,Marcello Vitaliti,Mariarosaria Maresi,Andrea Catzola,Laura Salvadori,Carmela Colangelo,Giovanni Marsicovetere,Michele D’Andria,Domenica Passarella,Carmela Genovese,Mari A. Orlando,Stefania Barrale,Maria R. Bonaccorso,Annalisa D’Arpa +231 more
TL;DR: In this lecture, it is highlighted how changes in the intestinal microenvironment, with a particular focus on the intestinal microbiota, impact upon respiratory disease.
Journal ArticleDOI
WS06-4 Ivacaftor (IVA) treatment in patients 6 to <12 months old with cystic fibrosis with a CFTR gating mutation: results of a 2-part, single-arm, phase 3 study
Jane C. Davies,Linda T Wang,Paul Panorchan,Daniel Campbell,S. Tian,Mark Higgins,O. Egbuna,Charlotte M. McKee,Margaret Rosenfeld +8 more