Journal ArticleDOI
Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin – An in vitro and in silico approach
Kumaravel Mohankumar,Sankar Pajaniradje,Subhashree Sridharan,Vivek Singh,Larance Ronsard,Akhil C. Banerjea,Chellakkan Selvanesan Benson,Mohane Selvaraj Coumar,Rukkumani Rajagopalan +8 more
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TLDR
Overall results showed that BDMC-A induced apoptosis more effectively compared to curcumin and the activity can be attributed to the presence of hydroxyl group in the ortho position in its structure.About:
This article is published in Chemico-Biological Interactions.The article was published on 2014-03-05. It has received 50 citations till now. The article focuses on the topics: Curcumin & MCF-7.read more
Citations
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Journal ArticleDOI
Caspase-9 as a therapeutic target for treating cancer.
TL;DR: The regulators of caspase-9 including microRNAs, natural compounds that are related to caspases and ongoing clinical trials are elucidated to better understand the casp enzyme-9 in suppressing cancer.
Journal ArticleDOI
Nanostructured lipid carriers enhance the bioavailability and brain cancer inhibitory efficacy of curcumin both in vitro and in vivo.
TL;DR: The work indicated the medical application of NLC-Cur on brain cancer treatment, and also provided a novel method for new anticancer agents’ development.
Journal ArticleDOI
Natural products against cancer angiogenesis.
El Bairi Khalid,EL-Meghawry EL-Kenawy Ayman,Heshu Sulaiman Rahman,Heshu Sulaiman Rahman,Guaadaoui Abdelkarim,Agnieszka Najda +5 more
TL;DR: The aim of this literature review article is to present the current state of knowledge concerning the molecular targets of tumorAngiogenesis and the active substances derived from natural sources, whose activity against cancer angiogenesis has been confirmed.
Journal ArticleDOI
Natural inhibitors of PI3K/AKT signaling in breast cancer: Emphasis on newly-discovered molecular mechanisms of action
Yaghoub Safdari,Yaghoub Safdari,Masoumeh Khalili,Mohammad Ali Ebrahimzadeh,Yaghoub Yazdani,Safar Farajnia +5 more
TL;DR: This review evaluates natural compounds that, in vitro (breast cancer cell lines) and/or in vivo (animal model, clinical) studies, suppress breast cancer cells or tumors mainly by suppressing the PI3K/AKT signaling pathway.
Journal ArticleDOI
Betanin‐Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF‐7 Cells
Laetitia Nowacki,Pascale Vigneron,Laura Rotellini,Hélène Cazzola,Franck Merlier,Elise Prost,Robert Ralanairina,Jean-Pierre Gadonna,Claire Rossi,Muriel Vayssade +9 more
TL;DR: The data bring new insight to consider the betanin/isobetanin mix as therapeutic anticancer compound, alone or in combination with classical chemotherapeutic drugs, especially in functional p53 tumors.
References
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Journal ArticleDOI
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
Journal ArticleDOI
Apoptosis: A Review of Programmed Cell Death
TL;DR: The goal of this review is to provide a general overview of current knowledge on the process of apoptosis including morphology, biochemistry, the role of apoptoses in health and disease, detection methods, as well as a discussion of potential alternative forms of apoptotic proteins.
Journal ArticleDOI
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
T Miyashita,John C. Reed +1 more
TL;DR: The bax gene promoter region contains four motifs with homology to consensus p53-binding sites and wild-type but not mutant p53 protein bound to oligonucleotides corresponding to this region of the bax promoter, suggesting that bax is a p53 primary-response gene, presumably involved in a p 53-regulated pathway for induction of apoptosis.
Book ChapterDOI
Curcumin: The Indian solid gold
TL;DR: Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease, and other chronic illnesses.
Journal ArticleDOI
Structural Determinants of Phosphoinositide 3-kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine
Edward H. Walker,Michael E. Pacold,Olga Perisic,Len R. Stephens,Philip T. Hawkins,Matthias P. Wymann,Roger L. Williams +6 more
TL;DR: Interestingly, LY294002 and the lead compound on which it was designed, quercetin, as well as the closely related flavonoid myricetin bind PI3K in remarkably different orientations that are related to each other by 180 degrees rotations.