Chen Chang

TL;DR: These integrated investigations of spatial ITH and clonal evolution provide an important molecular foundation for enhanced understanding of tumorigenesis and progression in ESCC.

TL;DR: The data suggest that miR-1224-5p downregulation is a frequent alteration in ESCC that promotes cell proliferation, migration, invasion and tumour growth by activating the EGFR-EFNA1/EPHA2-VEGFA signalling pathway via inhibition of TNS4 expression.

TL;DR: Both PIK3CA mutations and its downstream effector p-mTOR expression were two important regulators for activating the PI3K/Akt/mTOR pathway and may contribute to the targeted therapy for TNBC patients with poor outcome.

TL;DR: Aberrant mTOR activation was significantly associated with the risk of recurrence or death in patients with stage II and III CRC, thus this activated proteins that may serve as a potential biomarker for high-risk CRC.

TL;DR: In this article, the authors used a ProcartaPlex Array to screen for serum proteins that were increased in 40 esophageal squamous cell cancer (ESCC) patients compared with matched normal controls; they found that eight proteins (IL-2, IL-5, IP-10, IL 8, eotaxin, TNF-α, HGF, and MIP-1b) had higher serum levels in ESCC patients than in normal controls.