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Anand Mayakonda
Researcher at National University of Singapore
Publications - Â 52
Citations - Â 4390
Anand Mayakonda is an academic researcher from National University of Singapore. The author has contributed to research in topics: Gene silencing & Epigenetics. The author has an hindex of 22, co-authored 47 publications receiving 2339 citations. Previous affiliations of Anand Mayakonda include Heidelberg University & German Cancer Research Center.
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Journal ArticleDOI
Maftools: efficient and comprehensive analysis of somatic variants in cancer.
Anand Mayakonda,Anand Mayakonda,De-Chen Lin,Yassen Assenov,Yassen Assenov,Christoph Plass,Christoph Plass,H. Phillip Koeffler,H. Phillip Koeffler +8 more
TL;DR: An R Bioconductor package, Maftools, is described, which offers a multitude of analysis and visualization modules that are commonly used in cancer genomic studies, including driver gene identification, pathway, signature, enrichment, and association analyses, and is independent of larger alignment files.
Journal ArticleDOI
Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma
Jia-Jie Hao,De-Chen Lin,De-Chen Lin,Huy Q. Dinh,Anand Mayakonda,Yan-Yi Jiang,Chen Chang,Ye Jiang,Chen-Chen Lu,Zhi-Zhou Shi,Xin Xu,Yu Zhang,Yan Cai,Jin-Wu Wang,Qimin Zhan,Wen-Qiang Wei,Benjamin P. Berman,Ming-Rong Wang,H. Phillip Koeffler,H. Phillip Koeffler +19 more
TL;DR: These integrated investigations of spatial ITH and clonal evolution provide an important molecular foundation for enhanced understanding of tumorigenesis and progression in ESCC.
Journal ArticleDOI
Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse
Manoj Garg,Yasunobu Nagata,Deepika Kanojia,Anand Mayakonda,Kenichi Yoshida,Sreya Haridas Keloth,Zhi Jiang Zang,Yusuke Okuno,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Satoru Miyano,Ling-Wen Ding,Tamara Alpermann,Qiao-Yang Sun,De-Chen Lin,Wenwen Chien,Vikas Madan,Li Zhen Liu,Kar Tong Tan,Abhishek Sampath,Subhashree Venkatesan,Koiti Inokuchi,Satoshi Wakita,Hiroki Yamaguchi,Wee Joo Chng,Shirley Kow Yin Kham,Allen Eng Juh Yeoh,Masashi Sanada,Joanna Schiller,Karl Anton Kreuzer,Steven M. Kornblau,Hagop M. Kantarjian,Torsten Haferlach,Michael Lill,Ming Chung Kuo,Lee Yung Shih,Igor Wolfgang Blau,Olga Blau,Henry Yang,Seishi Ogawa,H. Phillip Koeffler,H. Phillip Koeffler +42 more
TL;DR: This study clearly shows that FLT3-ITD AML requires additional driver genetic alterations in addition to FLT2-ITd alone, and DNMT3A mutations are the most stable mutations.
Journal ArticleDOI
Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma
Jian-Jun Xie,Jian-Jun Xie,Yan-Yi Jiang,Yuan Jiang,Chunquan Li,Mei Chee Lim,Omer An,Anand Mayakonda,Ling-Wen Ding,Lin Long,Chun Sun,Le Hang Lin,Li Chen,Jian Yi Wu,Zhi-Yong Wu,Qi Cao,Wang-Kai Fang,Wei Yang,Harmik J. Soukiasian,Stephen J. Meltzer,Henry Yang,Melissa J. Fullwood,Melissa J. Fullwood,Li-Yan Xu,En-Min Li,De-Chen Lin,H. Phillip Koeffler,H. Phillip Koeffler +27 more
TL;DR: A lncRNA is identified, LINC01503, which is regulated by a super enhancer and is expressed at significantly higher levels in esophageal and head and neck SCCs than in non-tumor tissues and might be developed as a biomarker of aggressive S CCs in patients.
Journal ArticleDOI
Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma
Yan-Yi Jiang,De-Chen Lin,De-Chen Lin,Anand Mayakonda,Masaharu Hazawa,Ling-Wen Ding,Wenwen Chien,Liang Xu,Ye Chen,Jin Fen Xiao,William Senapedis,Erkan Baloglu,Deepika Kanojia,Li Shang,Xin Xu,Henry Yang,Jeffrey W. Tyner,Ming Rong Wang,H. Phillip Koeffler,H. Phillip Koeffler +19 more
TL;DR: Integrative approaches led to a catalogue of SE-associated master regulators and oncogenic transcripts, which may significantly promote both the understanding of OSCC biology and the development of more innovative therapies.