Chen Wang

TL;DR: Significant molecular differences exist between ER+ BC that recur early vs. much later despite adjuvant TAM, and exploiting these differences will improve the understanding of involved signaling pathways, allow for the reliable prediction of early treatment failure, and guide use of novel therapeutics specifically directed at preventing E vs L recurrences on endocrine therapy.

TL;DR: An innovative approach integrating Theory of Inventive Problem Solving (TRIZ) evolution theory and technology maturity mapping system is proposed to forecast the evolution trends of desoldering technology of waste printed circuit boards, predicting the law of energy conductivity and increasing the degree of idealisation.

TL;DR: CRFs can be considered as a proxy for representing information needs for their respective cancer types and can serve as a valuable resource for expanding existing standards to ensure they can comprehensively represent relevant clinical data without loss of granularity.

TL;DR: The results provide the first demonstration that benign breast tissue contains transcriptional alterations that indicate risk of breast cancer development, demonstrating that essential precursor biomarkers of malignancy are present many years prior to cancer development.

TL;DR: The largest cohort of RNA-seq from endometrioid OC to date, identified six hypermutated samples likely driven by POLE, which suggests the clinical need to screen for POLE driver mutations in endometioid OC, which can guide enrollment in immunotherapy clinical trials.