S
S. John Weroha
Researcher at Mayo Clinic
Publications - 74
Citations - 2790
S. John Weroha is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Medicine & Ovarian cancer. The author has an hindex of 18, co-authored 49 publications receiving 1825 citations. Previous affiliations of S. John Weroha include University of Rochester & Cedars-Sinai Medical Center.
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Journal ArticleDOI
Senolytics improve physical function and increase lifespan in old age
Ming Xu,Ming Xu,Tamar Pirtskhalava,Joshua N. Farr,Bettina M. Weigand,Bettina M. Weigand,Allyson K. Palmer,Megan M. Weivoda,Christina L. Inman,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Christine M Hachfeld,Daniel G. Fraser,Jennifer L Onken,Kurt O. Johnson,Grace C Verzosa,Larissa G.P. Langhi,Moritz Weigl,Nino Giorgadze,Nathan K. LeBrasseur,Jordan D. Miller,Diana Jurk,Ravinder J. Singh,David B. Allison,David B. Allison,Keisuke Ejima,Keisuke Ejima,Gene B. Hubbard,Yuji Ikeno,Yuji Ikeno,Hajrunisa Cubro,Vesna D. Garovic,Xiaonan Hou,S. John Weroha,Paul D. Robbins,Laura J. Niedernhofer,Sundeep Khosla,Tamara Tchkonia,James L. Kirkland +38 more
TL;DR: It is demonstrated that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.
Journal ArticleDOI
IGF-1 receptor inhibitors in clinical trials--early lessons.
S. John Weroha,Paul Haluska +1 more
TL;DR: The role of IGF-1 signaling in resistance to clinically important breast cancer therapies, including cytotoxic chemotherapy, hormonal therapy and erbB targeted agents is examined.
Journal ArticleDOI
The insulin-like growth factor system in cancer.
S. John Weroha,Paul Haluska +1 more
TL;DR: The modest benefits reported thus far underscore the need for a better understanding of IGF signaling, which would enable clinicians to identify the subset of patients with the greatest likelihood of attaining benefit from this targeted approach.
Journal ArticleDOI
Tumorgrafts as In Vivo Surrogates for Women with Ovarian Cancer
S. John Weroha,Marc A. Becker,Sergio Enderica-Gonzalez,Sean C. Harrington,Ann L. Oberg,Matthew J. Maurer,Sarah E. Perkins,Mariam M. AlHilli,Kristina A. Butler,Sarah McKinstry,Stephanie R. Fink,Robert B. Jenkins,Xiaonan Hou,Kimberly R. Kalli,Karin Goodman,Jann N. Sarkaria,Beth Y. Karlan,Amanika Kumar,Scott H. Kaufmann,Lynn C. Hartmann,Paul Haluska +20 more
TL;DR: This is the largest known living tumor bank of patient-derived, ovarian tumorgraft models that can be applied to the development of personalized cancer treatment and response to platinum chemotherapy correlates with the source patient.
Journal ArticleDOI
PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.
Terrence F. Meehan,Nathalie Conte,Theodore C. Goldstein,Giorgio Inghirami,Mark A. Murakami,Sebastian Brabetz,Zhiping Gu,Jeffrey Wiser,Patrick Dunn,Dale A. Begley,Debra M. Krupke,Andrea Bertotti,Alejandra Bruna,Matthew H. Brush,Annette T. Byrne,Carlos Caldas,Amanda L. Christie,Dominic Clark,Heidi Dowst,Jonathan R. Dry,James H. Doroshow,Olivier Duchamp,Yvonne A. Evrard,Stephane Ferretti,Kristopher K. Frese,Neal Goodwin,Danielle Greenawalt,Melissa A. Haendel,Els Hermans,Peter J. Houghton,Jos Jonkers,Kristel Kemper,Tin Oo Khor,Michael T. Lewis,Kevin C K Lloyd,Jeremy Mason,Enzo Medico,Steven B. Neuhauser,James M. Olson,Daniel S. Peeper,Oscar M. Rueda,Je Kyung Seong,Livio Trusolino,Emilie Vinolo,Robert J. Wechsler-Reya,David M. Weinstock,Alana L. Welm,S. John Weroha,Frédéric Amant,Frédéric Amant,Stefan M. Pfister,Stefan M. Pfister,Marcel Kool,Helen Parkinson,Atul J. Butte,Carol J. Bult +55 more
TL;DR: The PDX models minimal information standard (PDX-MI) is presented, which defines the minimal information for describing the clinical attributes of a patient's tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use ofPDX models in cancer research.