Chen Wang

TL;DR: This work has shown that complete resection at primary debulking surgery is the single most important prognostic factor in AOC and has the potential to improve the prognostic quality of AOC transplants.

Abstract: We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours.

TL;DR: In this paper, a pipe is externally provided with two groups of clamping rings with upper half rings and lower half rings, wherein one ends of the upper half ring and the lower half ring are opened and spaced; an upper connecting plate and a lower connecting plate are arranged in the axial direction; and the upper and lower rings are fastened by using bolts, handles arranged above the bolts and hinge mechanisms arranged below the bolts.

TL;DR: With the aid of DL, TSR evaluation could be generalized to large cohort to enable prognostic association analysis and facilitate discovering novel gene and pathways associated with disease progress.