Chen Wang

TL;DR: It is suggested that the minor allele of rs7874043 confers poor PFS by increasing PSIP1 expression, which is known to protect cells from stress-induced apoptosis, and high expression is associated withpoor PFS in EOC patients.

TL;DR: An effective bioinformatics strategy was devised and validated to separate mouse stroma expression from human tumor expression for PDX RNAseq and showed most of the PDX-donor differentially expressed genes were implicated in stromal components.

TL;DR: PAPP-A was detected in almost all breast cancer specimens and a more intense and greater extent of its expression was associated with luminal B specimens compared to luminal A specimens, and the role of P APP-A in breast cancer prognosis, and possibly therapeutics, warrants further investigation.

TL;DR: In this article, the authors evaluated the impact of wet-lab and bioinformatics approaches to optimize variant detection from FFPE samples, and they found that five times or more variants were called with these samples, compared to their paired fresh-frozen tissue samples even after applying molecular barcoding error-correction and default bio-formatics filtering recommended by the vendor.

TL;DR: The analysis suggests that either two or three, but not four, gene expression subtypes are most consistent across datasets, and early results favoring four subtypes may have been driven by the inclusion of serous borderline tumors.