Cheng Wang

TL;DR: These results implicate altered phosphate homeostasis in the etiology of IBGC and identify mutations in SLC20A2, encoding the type III sodium-dependent phosphate transporter 2 (PiT2), in IBGC-affected families of varied ancestry.

TL;DR: The results suggest that gain-of-function mutations in SCN11A can be causative of an autosomal-dominant episodic pain disorder.

TL;DR: ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with increased risk for severe COVID-19 as discussed by the authors, but it is unclear whether ApoE4 alters COVID19 susceptibility or severity, and the role of direct viral infection in brain cells remains obscure.

TL;DR: It is shown that infection of human-induced pluripotent-stem-cell-derived brain organoids by a “clinical-like” HCMV strain results in reduced brain organoid growth, impaired formation of cortical layers, and abnormal calcium signaling and neural network activity and can be prevented by neutralizing antibodies that recognize the H CMV pentamer complex.

TL;DR: It is shown that the pseudouridine synthase P US7 is highly expressed in glioblastoma versus normal brain tissues, and high PUS7 expression levels are associated with worse survival in glooblastomas patients, and preclinical evidence of a potential therapeutic strategy for gliOBlastoma is provided.