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Guoqiang Sun
Researcher at Beckman Research Institute
Publications - 30
Citations - 4953
Guoqiang Sun is an academic researcher from Beckman Research Institute. The author has contributed to research in topics: Neural stem cell & Stem cell. The author has an hindex of 24, co-authored 29 publications receiving 4126 citations. Previous affiliations of Guoqiang Sun include City of Hope National Medical Center.
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Journal ArticleDOI
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
Qi Cui,Hailing Shi,Peng Ye,Li Li,Qiuhao Qu,Guoqiang Sun,Guihua Sun,Zhike Lu,Yue Huang,Cai-Guang Yang,Arthur D. Riggs,Chuan He,Yanhong Shi +12 more
TL;DR: M6A sequencing reveals that knockdown of METTL3 or METTL14 induced changes in mRNA m6A enrichment and altered mRNA expression of genes with critical biological functions in GSCs, identified as promising therapeutic targets for glioblastoma.
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Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis
Miranda Y. Fong,Weiying Zhou,Liang Liu,Aileen Y. Alontaga,Manasa Chandra,Jonathan Ashby,Amy Y. M. Chow,Sean Timothy Francis O’Connor,Shasha Li,Andrew R. Chin,George Somlo,Melanie R. Palomares,Zhuo Li,Jacob R. Tremblay,Akihiro Tsuyada,Guoqiang Sun,Michael A. Reid,Xiwei Wu,Piotr Swiderski,Xiubao Ren,Yanhong Shi,Mei Kong,Wenwan Zhong,Yuan Chen,Shizhen Emily Wang +24 more
TL;DR: It is demonstrated that, by modifying glucose utilization by recipient premetastatic niche cells, cancer-derived extracellular miR-122 is able to reprogram systemic energy metabolism to facilitate disease progression.
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A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
TL;DR: It is shown that miR-9 suppresses TLX expression to negatively regulate neural stem cell proliferation and accelerate neural differentiation and forms a negative regulatory loop with TLX, which provides a model for controlling the balance between neural stem Cell proliferation and differentiation.
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MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling
TL;DR: Let-7b establishes an efficient strategy to control neural stem cell proliferation and differentiation by targeting the stem cell regulator TLX and the cell cycle regulator cyclin D1.
Journal ArticleDOI
Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal.
Qiuhao Qu,Guoqiang Sun,Wen-Wu Li,Su Yang,Peng Ye,Chunnian Zhao,Ruth T. Yu,Fred H. Gage,Ronald M. Evans,Yanhong Shi +9 more
TL;DR: The hypothesis that TLX acts through the Wnt/β-catenin pathway to regulate neural stem cell proliferation and self-renewal is supported and this study suggests that neural stem cells can promote their own self-Renewal by secreting signalling molecules that act in an autocrine/paracrine mode.