Y
Yanhong Shi
Researcher at Beckman Research Institute
Publications - 109
Citations - 11636
Yanhong Shi is an academic researcher from Beckman Research Institute. The author has contributed to research in topics: Neural stem cell & Stem cell. The author has an hindex of 41, co-authored 82 publications receiving 9753 citations. Previous affiliations of Yanhong Shi include City of Hope National Medical Center & Northwestern University.
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Journal ArticleDOI
Induced pluripotent stem cell technology: a decade of progress
TL;DR: The progress in applications of iPSC technology that are particularly relevant to drug discovery and regenerative medicine are discussed, and the remaining challenges and the emerging opportunities in the field are considered.
Journal ArticleDOI
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
Qi Cui,Hailing Shi,Peng Ye,Li Li,Qiuhao Qu,Guoqiang Sun,Guihua Sun,Zhike Lu,Yue Huang,Cai-Guang Yang,Arthur D. Riggs,Chuan He,Yanhong Shi +12 more
TL;DR: M6A sequencing reveals that knockdown of METTL3 or METTL14 induced changes in mRNA m6A enrichment and altered mRNA expression of genes with critical biological functions in GSCs, identified as promising therapeutic targets for glioblastoma.
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Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis
Miranda Y. Fong,Weiying Zhou,Liang Liu,Aileen Y. Alontaga,Manasa Chandra,Jonathan Ashby,Amy Y. M. Chow,Sean Timothy Francis O’Connor,Shasha Li,Andrew R. Chin,George Somlo,Melanie R. Palomares,Zhuo Li,Jacob R. Tremblay,Akihiro Tsuyada,Guoqiang Sun,Michael A. Reid,Xiwei Wu,Piotr Swiderski,Xiubao Ren,Yanhong Shi,Mei Kong,Wenwan Zhong,Yuan Chen,Shizhen Emily Wang +24 more
TL;DR: It is demonstrated that, by modifying glucose utilization by recipient premetastatic niche cells, cancer-derived extracellular miR-122 is able to reprogram systemic energy metabolism to facilitate disease progression.
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An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.
Wen Xie,Anna Radominska-Pandya,Yanhong Shi,Cynthia M. Simon,Michael C. Nelson,Erwin S. Ong,David J. Waxman,Ronald M. Evans +7 more
TL;DR: It is shown that activation of SXR/PXR is necessary and sufficient to both induce CYP3A enzymes and confer resistance to toxicity by LCA, as well as other xenotoxicants such as tribromoethanol and zoxazolamine.
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Molecular chaperones as HSF1-specific transcriptional repressors.
TL;DR: Results reveal that the repression of heat shock gene transcription, which occurs during attenuation, is due to the association of Hsp70 with the HSF1 transactivation domain, thus providing a plausible explanation for the role of molecular chaperones in at least one key step in the autoregulation of the heat shock response.