C
Chenran Wang
Researcher at University of Michigan
Publications - 6
Citations - 953
Chenran Wang is an academic researcher from University of Michigan. The author has contributed to research in topics: Autophagy & Stem cell. The author has an hindex of 6, co-authored 6 publications receiving 853 citations.
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Journal ArticleDOI
Autophagy in stem cells
Jun-Lin Guan,Anna Katharina Simon,Mark Prescott,Javier A. Menendez,Fei Liu,Fen Wang,Chenran Wang,Ernst J. Wolvetang,Alejandro Vazquez-Martin,Jue Zhang +9 more
TL;DR: A comprehensive review of the current understanding of the mechanisms and regulation of autophagy in embryonic stem cells, several tissue stem cells (particularly hematopoietic stem cells), as well as a number of cancer stem cells is provided.
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Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration
TL;DR: It is shown that neural-specific deletion of FIP200 resulted in cerebellar degeneration accompanied by progressive neuronal loss, spongiosis, and neurite degeneration in the cerebellum, providing strong genetic evidence for a role of Fip200 in the regulation of neuronal homeostasis through its function in autophagy in vivo.
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Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells
Ming Luo,Huaping Fan,Tamas Nagy,Huijun Wei,Chenran Wang,Suling Liu,Max S. Wicha,Jun-Lin Guan +7 more
TL;DR: Target deletion of FAK in mouse mammary epithelium significantly suppresses mammary tumorigenesis in a well-characterized breast cancer model and provides a novel mechanism by which FAK may promote breast cancer development and progression.
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FIP200 is required for maintenance and differentiation of postnatal neural stem cells
TL;DR: It is reported that ablation of FIP200, a gene essential for autophagy induction in mammalian cells, results in a progressive loss of neural stem cells (NSCs) and impairment in neuronal differentiation specifically in the postnatal brain, but not the embryonic brain, in mice.
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Regulation of Integrin β1 Recycling to Lipid Rafts by Rab1a to Promote Cell Migration
TL;DR: Results suggest a novel function for Rab1a in the regulation of cell migration through controlling integrin β1 recycling and localization to lipid rafts via a specific downstream effector pathway.