C
Cheryl Ingram-Smith
Researcher at Pennsylvania State University
Publications - 14
Citations - 1016
Cheryl Ingram-Smith is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Acetate kinase & Methanosarcina thermophila. The author has an hindex of 9, co-authored 12 publications receiving 980 citations. Previous affiliations of Cheryl Ingram-Smith include University of Illinois at Urbana–Champaign & Washington University in St. Louis.
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Journal ArticleDOI
The Genome of M. Acetivorans Reveals Extensive Metabolic and Physiological Diversity
James E. Galagan,Chad Nusbaum,Alice Roy,Matthew G. Endrizzi,Matthew G. Endrizzi,Matthew G. Endrizzi,Pendexter Macdonald,Pendexter Macdonald,Pendexter Macdonald,William Fitzhugh,Sarah E. Calvo,Reinhard Engels,Serge Smirnov,Deven Atnoor,Adam Brown,Nicole R. Allen,Nicole R. Allen,Nicole R. Allen,Jerome Naylor,Nicole Stange-Thomann,Kurt DeArellano,Robin Johnson,Lauren Linton,Paul A. McEwan,Kevin McKernan,Jessica A. Talamas,Andrea Tirrell,Andrea Tirrell,Wenjuan Ye,Wenjuan Ye,Andrew Zimmer,Robert D. Barber,Isaac K. O. Cann,David E. Graham,David A. Grahame,Adam M. Guss,Reiner Hedderich,Cheryl Ingram-Smith,Cheryl Ingram-Smith,Cheryl Ingram-Smith,H. Craig Kuettner,Joseph A. Krzycki,Joseph A. Krzycki,John A. Leigh,Weixi Li,Jinfeng Liu,Biswarup Mukhopadhyay,John N. Reeve,Kerry S. Smith,Timothy A. Springer,Timothy A. Springer,Timothy A. Springer,Lowell Umayam,Owen White,Robert H. White,Everly Conway de Macario,Everly Conway de Macario,James G. Ferry,Ken F. Jarrell,Ken F. Jarrell,Hua Jing,Hua Jing,Hua Jing,Alberto J.L. Macario,Ian T. Paulsen,Ian T. Paulsen,Ian T. Paulsen,Matthew A. Pritchett,Kevin R. Sowers,Ronald V. Swanson,Steven H. Zinder,Steven H. Zinder,Eric S. Lander,Eric S. Lander,Eric S. Lander,William W. Metcalf,Bruce W. Birren +76 more
TL;DR: The complete genome sequence of an acetate-utilizing methanogen, Methanosarcina acetivorans C2A, is reported, which indicates the likelihood of undiscovered natural energy sources for methanogenesis, whereas the presence of single-subunit carbon monoxide dehydrogenases raises the possibility of nonmethanogenic growth.
Journal ArticleDOI
Urkinase: Structure of Acetate Kinase, a Member of the ASKHA Superfamily of Phosphotransferases
Kathryn A. Buss,David R. Cooper,Cheryl Ingram-Smith,James G. Ferry,David Avram Sanders,Miriam S. Hasson +5 more
TL;DR: Structural, biochemical, and geochemical considerations indicate that an acetate kinase may be the ancestral enzyme of the ASKHA (acetate and sugar kinases/Hsc70/actin) superfamily of phosphotransferases.
Journal ArticleDOI
Characterization of the Acetate Binding Pocket in the Methanosarcina thermophila Acetate Kinase
Cheryl Ingram-Smith,Andrea Gorrell,Sarah H. Lawrence,Prabha Iyer,Kerry S. Smith,James G. Ferry +5 more
TL;DR: In this article, a solvent-accessible hydrophobic pocket formed by residues Val93, Leu122, Phe179, and Pro232 in the active site cleft was identified as a potential acetate binding site.
Journal ArticleDOI
Identification of Essential Glutamates in the Acetate Kinase from Methanosarcina thermophila
TL;DR: Alignment of the amino acid sequences for the acetate kinases from E. coli, Methanosarcina thermophila, and four other phylogenetically divergent microbes revealed high identity which included five glutamates, which indicates that neither residue is essential for catalysis or significantly influences the binding of acetate or ATP.
Journal ArticleDOI
Roles of the Conserved Aspartate and Arginine in the Catalytic Mechanism of an Archaeal β-Class Carbonic Anhydrase
TL;DR: The roles of an aspartate and an arginine, which are completely conserved in the active sites of beta-class carbonic anhydrases, were investigated by steady-state kinetic analyses of replacement variants of the beta- class enzyme (Cab) from the archaeon Methanobacterium thermoautotrophicum.