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Chester E. Chamberlain
Researcher at University of California, San Francisco
Publications - 20
Citations - 1859
Chester E. Chamberlain is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Cell. The author has an hindex of 14, co-authored 17 publications receiving 1741 citations. Previous affiliations of Chester E. Chamberlain include Scripps Research Institute & Harvard University.
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Journal ArticleDOI
Localized Rac Activation Dynamics Visualized in Living Cells
Vadim Kraynov,Chester E. Chamberlain,Gary M. Bokoch,Martin A. Schwartz,Sarah Slabaugh,Klaus M. Hahn +5 more
TL;DR: A method called FLAIR (fluorescence activation indicator for Rho proteins) was developed to quantify the spatio-temporal dynamics of the Rac1 nucleotide state in living cells, revealing precise spatial control of growth factor-induced Rac activation, in membrane ruffles and in a gradient of activation at the leading edge of motile cells.
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Rho Family Proteins Modulate Rapid Apoptosis Induced by Cytotoxic T Lymphocytes and Fas
M. Cecilia Subauste,Matthias von Herrath,Valerie Benard,Chester E. Chamberlain,Tsung-Hsien Chuang,Keting Chu,Gary M. Bokoch,Klaus M. Hahn +7 more
TL;DR: It is demonstrated that all three Rho family members are involved in CTL- and Fas-induced killing and the ability of Rac to enhance apoptosis was decreased by point mutations reported to block Rac induction of actin polymerization.
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Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning
TL;DR: This study genetically engineered mice to produce bioactive, fluorescently labeled Shh from the endogenous locus, and shows that Shh ligand concentrates in close association with the apically positioned basal body of neural target cells, forming a dynamic, punctate gradient in the ventral neural tube.
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Spatial and Temporal Analysis of Rac Activation during Live Neutrophil Chemotaxis
Elisabeth Gardiner,Kersi Pestonjamasp,Benjamin P. Bohl,Chester E. Chamberlain,Klaus M. Hahn,Gary M. Bokoch +5 more
TL;DR: Data establish that Rac GTPase is spatially and temporally regulated to coordinate leading-edge extension and tail retraction during a complex motile response, the chemotaxis of human neutrophils.
Journal ArticleDOI
Human pancreatic neuro-insular network in health and fatty infiltration.
Shiue-Cheng Tang,Luc Baeyens,Chia-Ning Shen,Shih-Jung Peng,Hung-Jen Chien,David W. Scheel,Chester E. Chamberlain,Michael S. German +7 more
TL;DR: It is strongly suggested that fatty infiltration in the human pancreas creates a neurotrophic microenvironment and promotes remodelling of pancreatic innervation via 3D histology.