M
Markus A. Queisser
Researcher at GlaxoSmithKline
Publications - 18
Citations - 1843
Markus A. Queisser is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Protein degradation & Ubiquitin ligase. The author has an hindex of 10, co-authored 16 publications receiving 1379 citations. Previous affiliations of Markus A. Queisser include Ludwig Institute for Cancer Research & Northwestern University.
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Journal ArticleDOI
Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones
Mona Saffarzadeh,Christiane Juenemann,Markus A. Queisser,Markus A. Queisser,Guenter Lochnit,Guillermo Barreto,Sebastian P. Galuska,Juergen Lohmeyer,Klaus T. Preissner +8 more
TL;DR: Data reveal the important role of protein components in NET, particularly histones, which may lead to host cell cytotoxicity and may be involved in lung tissue destruction.
Journal ArticleDOI
MiR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma
Fotini M. Kouri,Lisa A. Hurley,Weston L. Daniel,Emily S. Day,Youjia Hua,Liangliang Hao,Chian Yu Peng,Timothy J. Merkel,Markus A. Queisser,Carissa Ritner,Hailei Zhang,C. David James,Jacob I. Sznajder,Lynda Chin,David A. Giljohann,John A. Kessler,Marcus E. Peter,Chad A. Mirkin,Alexander H. Stegh +18 more
TL;DR: MiR-182 is identified as a regulator of apoptosis, growth, and differentiation programs whose expression level is correlated with GBM patient survival and harnessing the anti-tumor activities of miR- 182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM.
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Hyperglycemia Impairs Proteasome Function by Methylglyoxal
Markus A. Queisser,Dachun Yao,Sven Geisler,Hans-Peter Hammes,Günter Lochnit,Erwin Schleicher,Michael Brownlee,Klaus T. Preissner +7 more
TL;DR: Hyperglycemia-induced formation of MGO covalently modifies the 20S proteasome, decreasing its activity in the diabetic kidney and reducing the polyubiquitin receptor 19S-S5a.
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Loss of RAGE in pulmonary fibrosis: molecular relations to functional changes in pulmonary cell types.
Markus A. Queisser,Fotini M. Kouri,Melanie Königshoff,Malgorzata Wygrecka,Uwe Schubert,Oliver Eickelberg,Klaus T. Preissner +6 more
TL;DR: Results indicate that RAGE serves a protective role in the lung, and that loss of the receptor is related to functional changes of pulmonary cell types, with the consequences of fibrotic disease.
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The PROTACtable genome
Melanie Schneider,Chris J Radoux,Andrew Hercules,David Ochoa,Ian Dunham,Lykourgos-Panagiotis Zalmas,Gerhard Hessler,Sven Ruf,Veerabahu Shanmugasundaram,Michael M. Hann,Pamela Thomas,Markus A. Queisser,Andrew B. Benowitz,Kris Brown,Andrew R. Leach +14 more
TL;DR: In this article, the tractability of PROTAC-targeting chimeras is assessed using a series of criteria based on data and information from a diverse range of relevant publicly available resources.