Jacob I. Sznajder

TL;DR: The results support the feasibility of discovery-based approaches using next-generation sequencing technologies to identify signaling pathways for targeting in the development of personalized therapies for patients with pulmonary fibrosis.

TL;DR: Using transcriptomic profiling of flow-sorted cells, it is found that monocyte to alveolar macrophage differentiation unfolds continuously over the course of fibrosis and its resolution, and suggests that selectively targeting alveolars macrophages differentiation within the lung may ameliorate fibrosis without the adverse consequences associated with global monocyte or tissue-resident alve Polar Macrophage depletion.

TL;DR: It is suggested that inexperienced physicians should first attempt central vein catheterizations in unconscious and mechanically ventilated patients, whereas in conscious patients these rates were 70.5% and 13.8%, respectively.

TL;DR: It is suggested that inexperienced physicians should first attempt central vein catheterizations in unconscious and mechanically ventilated patients, whereas in conscious patients these rates were 70.5% and 13.8%, respectively.

TL;DR: It is concluded that small VT-high PEEP is a better mode of ventilating acute lung injury than large VT-low PEEP because edema accumulation is less and venous admixture is less.