C
Chikage Mataki
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 17
Citations - 6260
Chikage Mataki is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Insulin resistance & Receptor. The author has an hindex of 16, co-authored 17 publications receiving 5619 citations. Previous affiliations of Chikage Mataki include French Institute of Health and Medical Research.
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Journal ArticleDOI
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Mitsuhiro Watanabe,Sander M. Houten,Chikage Mataki,Marcelo A. Christoffolete,Brian W. Kim,Hiroyuki Sato,Nadia Messaddeq,John W. Harney,Osamu Ezaki,Tatsuhiko Kodama,Kristina Schoonjans,Antonio C. Bianco,Johan Auwerx +12 more
TL;DR: It is shown that the administration of BAs to mice increases energy expenditure in brown adipose tissue, preventing obesity and resistance to insulin, and indicates that BAs might be able to function beyond the control of BA homeostasis as general metabolic integrators.
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TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Charles Thomas,Antimo Gioiello,Lilia G. Noriega,Lilia G. Noriega,Axelle Strehle,Julien Oury,Giovanni Rizzo,Antonio Macchiarulo,Hiroyasu Yamamoto,Hiroyasu Yamamoto,Chikage Mataki,Chikage Mataki,Mark Pruzanski,Roberto Pellicciari,Johan Auwerx,Johan Auwerx,Kristina Schoonjans,Kristina Schoonjans +17 more
TL;DR: It is shown here that TGR5 signaling induces intestinal glucagon-like peptide-1 (GLP-1) release, leading to improved liver and pancreatic function and enhanced glucose tolerance in obese mice, and suggested that pharmacological targeting of T GR5 may constitute a promising incretin-based strategy for the treatment of diabesity and associated metabolic disorders.
Journal ArticleDOI
Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
Carles Cantó,Lake Q. Jiang,Atul S. Deshmukh,Chikage Mataki,Agnès Coste,Marie Lagouge,Juleen R. Zierath,Johan Auwerx +7 more
TL;DR: It is concluded that AMPK acts as the primordial trigger for fasting- and exercise-induced adaptations in skeletal muscle and that activation of SIRT1 and its downstream signaling pathways are improperly triggered in AMPK-deficient states.
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Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
Jerome N. Feige,Marie Lagouge,Carles Cantó,Axelle Strehle,Sander M. Houten,Jill C. Milne,Philip D. Lambert,Chikage Mataki,Peter J. Elliott,Johan Auwerx,Johan Auwerx +10 more
TL;DR: The metabolic phenotype of mice treated with SRT1720, a specific and potent synthetic activator of SIRT1 that is devoid of direct action on AMPK that robustly enhances endurance running performance and strongly protects from diet-induced obesity and insulin resistance by enhancing oxidative metabolism in skeletal muscle, liver, and brown adipose tissue is reported.
Journal ArticleDOI
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure
Mitsuhiro Watanabe,Yasushi Horai,Sander M. Houten,Kohkichi Morimoto,Taichi Sugizaki,Eri Arita,Chikage Mataki,Hiroyuki Sato,Yusuke Tanigawara,Kristina Schoonjans,Hiroshi Itoh,Johan Auwerx +11 more
TL;DR: This paper evaluated the metabolic impact of farnesoid X receptor activation by administering a synthetic FXR agonist (GW4064) to mice in which obesity was induced by a high fat diet.