TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Charles Thomas,Antimo Gioiello,Lilia G. Noriega,Lilia G. Noriega,Axelle Strehle,Julien Oury,Giovanni Rizzo,Antonio Macchiarulo,Hiroyasu Yamamoto,Hiroyasu Yamamoto,Chikage Mataki,Chikage Mataki,Mark Pruzanski,Roberto Pellicciari,Johan Auwerx,Johan Auwerx,Kristina Schoonjans,Kristina Schoonjans +17 more
TLDR
It is shown here that TGR5 signaling induces intestinal glucagon-like peptide-1 (GLP-1) release, leading to improved liver and pancreatic function and enhanced glucose tolerance in obese mice, and suggested that pharmacological targeting of T GR5 may constitute a promising incretin-based strategy for the treatment of diabesity and associated metabolic disorders.About:
This article is published in Cell Metabolism.The article was published on 2009-09-02 and is currently open access. It has received 1412 citations till now. The article focuses on the topics: G protein-coupled bile acid receptor & Glucose homeostasis.read more
Citations
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Journal ArticleDOI
Functional interactions between the gut microbiota and host metabolism
TL;DR: Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, the world will be in a better position to develop treatments for metabolic disease.
Journal ArticleDOI
The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
Journal ArticleDOI
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism.
TL;DR: Host metabolism can be affected through microbial modifications of bile acids, which lead to altered signaling via bile acid receptors, but also by altered microbiota composition.
Journal ArticleDOI
Gut microbiota in human metabolic health and disease.
Yong Fan,Oluf Pedersen +1 more
TL;DR: How the gut microbiota and derived microbial compounds may contribute to human metabolic health and to the pathogenesis of common metabolic diseases are discussed, and examples of microbiota-targeted interventions aiming to optimize metabolic health are highlighted.
Journal ArticleDOI
Thyroid Hormone Regulation of Metabolism
TL;DR: The role of TH in regulating metabolic pathways has led to several new therapeutic targets for metabolic disorders and understanding the mechanisms and interactions of the various TH signaling pathways in metabolism will improve the likelihood of identifying effective and selective targets.
References
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Abdominal obesity and metabolic syndrome
TL;DR: This work has shown that abdominal obesity — the most prevalent manifestation of metabolic syndrome — is a marker of 'dysfunctional adipose tissue', and is of central importance in clinical diagnosis.
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The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
TL;DR: Clinical trials with the incretin mimetic exenatide and liraglutide show reductions in fasting and postprandial glucose concentrations, and haemoglobin A1c (HbA1c) associated with weight loss, but long-term clinical studies are needed to determine the benefits of targeting the inc retin axis for the treatment of type 2 diabetes.
Journal ArticleDOI
The biology of incretin hormones.
TL;DR: Current concepts of incretin action are summarized and the potential therapeutic utility of GLP-1 receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes is highlighted.
Journal ArticleDOI
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Mitsuhiro Watanabe,Sander M. Houten,Chikage Mataki,Marcelo A. Christoffolete,Brian W. Kim,Hiroyuki Sato,Nadia Messaddeq,John W. Harney,Osamu Ezaki,Tatsuhiko Kodama,Kristina Schoonjans,Antonio C. Bianco,Johan Auwerx +12 more
TL;DR: It is shown that the administration of BAs to mice increases energy expenditure in brown adipose tissue, preventing obesity and resistance to insulin, and indicates that BAs might be able to function beyond the control of BA homeostasis as general metabolic integrators.
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Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.
Akira Hirasawa,Keiko Tsumaya,Takeo Awaji,Susumu Katsuma,Tetsuya Adachi,Masateru Yamada,Yukihiko Sugimoto,Shunichi Miyazaki,Gozoh Tsujimoto,Gozoh Tsujimoto +9 more
TL;DR: It is shown that a G-protein-coupled receptor, GPR120, which is abundantly expressed in intestine, functions as a receptor for unsaturated long-chain FFAs and promotes the secretion of GLP-1 in vitro and in vivo, and increases circulating insulin.