C
Chong Xu
Researcher at University of Pennsylvania
Publications - 4
Citations - 55
Chong Xu is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Human leukocyte antigen & Aplastic anemia. The author has an hindex of 2, co-authored 2 publications receiving 22 citations.
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Journal ArticleDOI
Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens.
Gerald P. Linette,Michelle Becker-Hapak,Zachary L. Skidmore,Miren L. Baroja,Chong Xu,Jasreet Hundal,David H. Spencer,Weixuan Fu,Casey L. Cummins,Maya G. Robnett,Saghar Kaabinejadian,William H. Hildebrand,Vincent Magrini,Ryan Demeter,Alexander S. Krupnick,Obi L. Griffith,Malachi Griffith,Elaine R. Mardis,Beatriz M. Carreno +18 more
TL;DR: Deep targeted DNA sequencing of multiple metastases from melanoma patients is performed and evidence that, despite ubiquitous sharing of clonal and subclonal neoantigens among tumors, the CD8+ response is limited to a small (<10%) subset of antigens and is typically mono-/oligoclonal in nature is provided.
Journal ArticleDOI
Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes.
Caitlin Ritz,Caitlin Ritz,Wenzhao Meng,Natasha Stanley,Natasha Stanley,Miren L. Baroja,Chong Xu,Patrick Yan,Alexander C. Huang,Alexander C. Huang,Ryan Hausler,Peter Nicholas,Jian-Meng Fan,David B. Lieberman,Beatriz M. Carreno,Beatriz M. Carreno,Eline T. Luning Prak,Timothy S. Olson,Daria V. Babushok,Daria V. Babushok +19 more
TL;DR: Acquired aplastic anemia is a T-cell–mediated autoimmune bone marrow aplasia, without a known etiologic trigger, that can occur following vaccination and accompany graft dysfunction or aplastics anemia relapse.
Journal ArticleDOI
Expression of inducible factors reprograms CAR-T cells for enhanced function and safety.
Anže Smole,Alexander Benton,Mathilde Poussin,Monika A. Eiva,Claudia Mezzanotte,Barbara Camisa,Beatrice Greco,Prannda Sharma,Nicholas G. Minutolo,Falon D. Gray,Adham S. Bear,Miren L. Baroja,Casey L. Cummins,Chong Xu,Francesca Sanvito,Andrea Lang Goldgewicht,Tatiana Blanchard,Alba Rodriguez-Garcia,Michael Klichinsky,Chiara Bonini,Carl H. June,Avery D. Posey,Gerald P. Linette,Beatriz M. Carreno,Monica Casucci,Daniel J Powell +25 more
TL;DR: Uni-Vect as discussed by the authors is a genetic platform that combines autonomous antigen-induced production of an accessory molecule with constitutive CAR expression in a single lentiviral vector called UniVect.
Journal ArticleDOI
Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities
Timothy S. Olson,Benjamin F Frost,J. L. Duke,Marian Dribus,Hongbo Xie,Zachary D. Prudowsky,Elissa Furutani,Jonas Gudera,Y. Shah,Deborah Ferriola,Amalia Dinou,Ioanna Pagkrati,Soyoung Kim,Yixi Xu,Meilun He,Shannon Zheng,Sally Nijim,Ping Lin,Chong Xu,Taizo A. Nakano,Joseph H. Oved,Beatriz M. Carreno,Yung-Tsi Bolon,Shahinaz M. Gadalla,Steven G.E. Marsh,Sophie Paczesny,Stephanie J. Lee,Dimitri S. Monos,Akiko Shimamura,Alison A. Bertuch,Loren Gragert,Stephen R. Spellman,Daria V. Babushok +32 more
TL;DR: It is demonstrated that HLA alleles confer different risks of developing AA, but once AA develops, specific alleles are not associated with response to immunosuppression or trans-plant outcomes, and higher pathogenicity alleles, particularly HLA-B*14:02, are associated with higher rates of clonal evolution in adult AA patients.