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Weixuan Fu
Researcher at University of Pennsylvania
Publications - 68
Citations - 1487
Weixuan Fu is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Gene & Population. The author has an hindex of 16, co-authored 57 publications receiving 917 citations. Previous affiliations of Weixuan Fu include University of Delaware & China Agricultural University.
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Journal ArticleDOI
Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction
Daniel K. Wells,Marit M. van Buuren,Kristen K. Dang,Vanessa M. Hubbard-Lucey,Kathleen C. F. Sheehan,Katie M. Campbell,Andrew Lamb,Jeffrey P. Ward,John Sidney,Ana Belen Blazquez,Andrew J. Rech,Jesse M. Zaretsky,Begonya Comin-Anduix,Alphonsus H. C. Ng,William Chour,Thomas Yu,Hira Rizvi,Jia M. Chen,Patrice Manning,Gabriela Steiner,Xengie Doan,Aly A. Khan,Amit A. Lugade,Ana M. Mijalkovic Lazic,Angela Frentzen,Arbel D. Tadmor,Ariella Sasson,Arjun A. Rao,Baikang Pei,Barbara Schrörs,Beata Berent-Maoz,Beatriz M. Carreno,Bin Song,Bjoern Peters,Bo Li,Brandon W. Higgs,Brian Stevenson,Christian Iseli,Christopher A. Miller,Christopher A. Morehouse,Cornelis J. M. Melief,Cristina Puig-Saus,Daphne van Beek,David Balli,David Gfeller,David Haussler,Dirk Jäger,Eduardo Cortes,Ekaterina Esaulova,Elham Sherafat,Francisco Arcila,Gabor Bartha,Geng Liu,George Coukos,Guilhem Richard,Han Chang,Han Si,Inka Zörnig,Ioannis Xenarios,Ion I. Mandoiu,Irsan Kooi,James P. Conway,Jan H. Kessler,Jason A. Greenbaum,Jason Perera,Jason Harris,Jasreet Hundal,Jennifer M. Shelton,Jianmin Wang,Jiaqian Wang,Joel Greshock,Jonathon Blake,Joseph D. Szustakowski,Julia Kodysh,Juliet Forman,Lei Wei,Leo J. Lee,Lorenzo F. Fanchi,Maarten Slagter,Maren Lang,Markus Mueller,Martin Löwer,Mathias Vormehr,Maxim N. Artyomov,Michael A. Kuziora,Michael F. Princiotta,Michal Bassani-Sternberg,Mignonette H. Macabali,Milica R. Kojicic,Naibo Yang,Nevena M. Ilic Raicevic,Nicolas Guex,Nicolas Robine,Niels Halama,Nikola M. Skundric,Ognjen Milicevic,Pascal Gellert,Patrick Jongeneel,Pornpimol Charoentong,Pramod K. Srivastava,Prateek Tanden,Priyanka Shah,Qiang Hu,Ravi Gupta,Richard Chen,Robert A. Petit,Robert Ziman,Rolf Hilker,Sachet A. Shukla,Sahar Al Seesi,Sean Michael Boyle,Si Qiu,Siranush Sarkizova,Sofie R. Salama,Song Liu,Song Wu,Sriram Sridhar,Steven L. C. Ketelaars,Suchit Jhunjhunwala,Tatiana Shcheglova,Thierry Schuepbach,Todd Creasy,Veliborka Josipovic,Vladimir B. Kovacevic,Weixuan Fu,Willem-Jan Krebber,Yi-Hsiang Hsu,Yinong Sebastian,Zeynep Kosaloglu Yalcin,Zhiqin Huang,Taha Merghoub,Taha Merghoub,Justin Guinney,Justin Guinney,Adam Kolom,Cheryl Selinsky,Antoni Ribas,Antoni Ribas,Matthew D. Hellmann,Nir Hacohen,Nir Hacohen,Alessandro Sette,Alessandro Sette,James R. Heath,Nina Bhardwaj,Fred Ramsdell,Robert D. Schreiber,Ton N. Schumacher,Pia Kvistborg,Nadine Defranoux +149 more
TL;DR: A model of tumor epitope immunogenicity was developed that filtered out 98% of non-immunogenic peptides with a precision above 0.70 and was validated in an independent cohort of 310 epitopes prioritized from tumor sequencing data and assessed for T cell binding.
Journal ArticleDOI
Scaling tree-based automated machine learning to biomedical big data with a feature set selector
TL;DR: Two new features implemented in TPOT that helps increase the system’s scalability: Feature Set Selector (FSS) and Template and help reduce TPOT computation time and may provide more interpretable results.
Journal ArticleDOI
Characterization of a novel chicken muscle disorder through differential gene expression and pathway analysis using RNA-sequencing.
TL;DR: There is convincing evidence by RNA-seq analysis to support localized hypoxia, oxidative stress, increased intracellular calcium, as key features of Wooden Breast Disease, which are supported by reported microscopic lesions of the disease.
Journal ArticleDOI
ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.
Feven Tameire,Ioannis I. Verginadis,Nektaria Maria Leli,Christine Polte,Crystal S. Conn,Rani Ojha,Carlo Salas Salinas,Frank Chinga,Alexandra M Monroy,Weixuan Fu,Paul P. Wang,Andrew V. Kossenkov,Jiangbin Ye,Ravi K. Amaravadi,Zoya Ignatova,Serge Y. Fuchs,J. Alan Diehl,Davide Ruggero,Constantinos Koumenis +18 more
TL;DR: An essential role is revealed for activating transcription factor 4 (ATF4) in survival following MYC activation, which establishes ATF4 as a cellular rheostat of MYC activity, which ensures that enhanced translation rates are compatible with survival and tumour progression.
Journal ArticleDOI
A genome-wide detection of copy number variations using SNP genotyping arrays in swine
TL;DR: This study provides a comprehensive map of copy number variation in the pig genome, which would be of help for understanding the Pig genome and provide preliminary foundation for investigating the association between various phenotypes and CNVs.