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Douglas A. Hosack
Researcher at Science Applications International Corporation
Publications - 10
Citations - 11514
Douglas A. Hosack is an academic researcher from Science Applications International Corporation. The author has contributed to research in topics: Normalization (statistics) & Gene expression. The author has an hindex of 9, co-authored 10 publications receiving 10679 citations. Previous affiliations of Douglas A. Hosack include National Institutes of Health.
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Journal ArticleDOI
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Glynn Dennis,Brad T. Sherman,Douglas A. Hosack,Jun Jun Yang,Wei Gao,H. Clifford Lane,Richard A. Lempicki +6 more
TL;DR: DAMID is a web-accessible program that integrates functional genomic annotations with intuitive graphical summaries that assists in the interpretation of genome-scale datasets by facilitating the transition from data collection to biological meaning.
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Identifying biological themes within lists of genes with EASE
TL;DR: EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE and other high-throughput genomic data and is robust to varying methods of normalization, intensity calculation and statistical selection of genes.
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PubMatrix: a tool for multiplex literature mining
Kevin G. Becker,Douglas A. Hosack,Glynn Dennis,Richard A. Lempicki,Tiffani J Bright,Chris Cheadle,James Engel +6 more
TL;DR: PubMatrix is a web-based tool that allows simple text based mining of the NCBI literature search service PubMed using any two lists of keywords terms, resulting in a frequency matrix of term co-occurrence, which can be assigned genetic, biological, or clinical relevance in a rapid flexible systematic fashion.
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HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication
Claudia Cicala,James Arthos,Sara Selig,Glynn Dennis,Douglas A. Hosack,Donald Van Ryk,Marion L. Spangler,Tavis D. Steenbeke,Prateeti Khazanie,Neil Gupta,Jun Yang,Marybeth Daucher,Richard A. Lempicki,Anthony S. Fauci +13 more
TL;DR: Examination of transcriptional changes induced by gp120 in freshly isolated peripheral blood mononuclear cells and monocyte-derived-macrophages reveals a broad and complex transcriptional program conducive to productive infection with HIV.
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Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients
Joseph A. Kovacs,Richard A. Lempicki,Igor A. Sidorov,Joseph W. Adelsberger,Irini Sereti,William Sachau,Grace Kelly,Julia A. Metcalf,Richard T. Davey,Judith Falloon,Michael A. Polis,Jorge A. Tavel,Randy Stevens,Laurie Lambert,Douglas A. Hosack,Marjorie Bosche,Haleem J. Issaq,Stephen D. Fox,Susan F. Leitman,Michael Baseler,Henry Masur,Michele Di Mascio,Dimiter S. Dimitrov,H. Clifford Lane +23 more
TL;DR: Examination of lymphocyte subsets demonstrated that phenotypically naive as well as central memory CD4 cells were preferentially expanded, suggesting that IL-2 can help maintain cells important for host defense against new antigens as well for long-term memory to opportunistic pathogens.