G
Glynn Dennis
Researcher at AstraZeneca
Publications - 20
Citations - 12204
Glynn Dennis is an academic researcher from AstraZeneca. The author has contributed to research in topics: Gene & Fc receptor. The author has an hindex of 13, co-authored 19 publications receiving 11302 citations. Previous affiliations of Glynn Dennis include Science Applications International Corporation & University of Alabama at Birmingham.
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Journal ArticleDOI
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Glynn Dennis,Brad T. Sherman,Douglas A. Hosack,Jun Jun Yang,Wei Gao,H. Clifford Lane,Richard A. Lempicki +6 more
TL;DR: DAMID is a web-accessible program that integrates functional genomic annotations with intuitive graphical summaries that assists in the interpretation of genome-scale datasets by facilitating the transition from data collection to biological meaning.
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Identifying biological themes within lists of genes with EASE
TL;DR: EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE and other high-throughput genomic data and is robust to varying methods of normalization, intensity calculation and statistical selection of genes.
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Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics
Glynn Dennis,Cecile T.J. Holweg,Sarah K. Kummerfeld,David F. Choy,A. Francesca Setiadi,Jason A. Hackney,Peter M. Haverty,Houston Gilbert,Wei Yu Lin,Lauri Diehl,Saloumeh K Fischer,An Song,David Musselman,Micki Klearman,Cem Gabay,Arthur Kavanaugh,Judith Endres,David A. Fox,Flavius Martin,Flavius Martin,Michael J. Townsend +20 more
TL;DR: It is demonstrated that underlying molecular and cellular heterogeneity in RA impacts clinical outcome to therapies targeting different biological pathways, with patients with the myeloid phenotype exhibiting the most robust response to anti-TNFα.
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PubMatrix: a tool for multiplex literature mining
Kevin G. Becker,Douglas A. Hosack,Glynn Dennis,Richard A. Lempicki,Tiffani J Bright,Chris Cheadle,James Engel +6 more
TL;DR: PubMatrix is a web-based tool that allows simple text based mining of the NCBI literature search service PubMed using any two lists of keywords terms, resulting in a frequency matrix of term co-occurrence, which can be assigned genetic, biological, or clinical relevance in a rapid flexible systematic fashion.
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Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals.
Tae-Wook Chun,J. Shawn Justement,Richard A. Lempicki,Jun Yang,Glynn Dennis,Claire W. Hallahan,Christina Sanford,Punita Pandya,Shuying Liu,Mary McLaughlin,Linda A. Ehler,Susan Moir,Anthony S. Fauci +12 more
TL;DR: It is suggested that active viral replication has a significant impact on the physiologic state of resting CD4+ T cells in infected viremic patients and, in turn, allows release of HIV-1 without exogenous activation stimuli.