C
Chrisovalantis Papadopoulos
Researcher at University of Duisburg-Essen
Publications - 15
Citations - 1056
Chrisovalantis Papadopoulos is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Endosome & DYRK1A. The author has an hindex of 11, co-authored 15 publications receiving 750 citations. Previous affiliations of Chrisovalantis Papadopoulos include RWTH Aachen University & Pompeu Fabra University.
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Journal ArticleDOI
Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation.
Nora Göckler,Guillermo Jofre,Chrisovalantis Papadopoulos,Ulf Soppa,Francisco J. Tejedor,Walter Becker +5 more
TL;DR: It is shown that harmine interferes with neuritogenesis in cultured hippocampal neurons and provides evidence for a role of DYRK1A in the regulation of neurite formation.
Journal ArticleDOI
VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.
Chrisovalantis Papadopoulos,Philipp Kirchner,Monika Bug,Daniel Grum,Lisa Koerver,Nina Schulze,Robert Poehler,Alina Dressler,Sven Fengler,Khalid Arhzaouy,Vanda Lux,Michael Ehrmann,Conrad C. Weihl,Hemmo Meyer +13 more
TL;DR: An essential role is identified for the ubiquitin‐directed AAA‐ATPase, p97, in the clearance of damaged lysosomes by autophagy, and the pathway is implicate as a modulator of degenerative diseases.
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Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and Lysophagy
TL;DR: This review aims to gather available data from different fields and to define the key steps necessary for sensing and subsequent clearance of damaged lysosomes, and to discuss the disease implications with a focus on neurodegeneration.
Journal ArticleDOI
Repair or Lysophagy: Dealing with Damaged Lysosomes.
TL;DR: Recent data on cellular damage sensing, the underlying ubiquitination and autophagy machinery as well as additional layers of regulation such as processing of ubiquitinated proteins by the AAA-ATPase VCP/p97 are discussed.
Journal ArticleDOI
Spastin binds to lipid droplets and affects lipid metabolism.
Chrisovalantis Papadopoulos,Genny Orso,Giuseppe Mancuso,Marija Herholz,Sentiljana Gumeni,Nimesha Tadepalle,Christian Jüngst,Anne Tzschichholz,Astrid Schauss,Stefan Höning,Aleksandra Trifunovic,Andrea Daga,Elena I. Rugarli +12 more
TL;DR: The data uncovers an evolutionarily conserved role of spastin as a positive regulator of LD metabolism and open up the possibility that dysfunction of LDs in axons may contribute to the pathogenesis of HSP.