R
Ralph Stadhouders
Researcher at Erasmus University Rotterdam
Publications - 82
Citations - 4591
Ralph Stadhouders is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Gene & Chromatin. The author has an hindex of 29, co-authored 68 publications receiving 3240 citations. Previous affiliations of Ralph Stadhouders include Pompeu Fabra University & Erasmus University Medical Center.
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Journal ArticleDOI
Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.
Ai Ing Lim,Ai Ing Lim,Ai Ing Lim,Yan Li,Yan Li,Silvia Lopez-Lastra,Silvia Lopez-Lastra,Silvia Lopez-Lastra,Ralph Stadhouders,Franziska Paul,Armanda Casrouge,Armanda Casrouge,Nicolas Serafini,Nicolas Serafini,Anne Puel,Anne Puel,Jacinta Bustamante,Jacinta Bustamante,Laura Surace,Laura Surace,Guillemette Masse-Ranson,Guillemette Masse-Ranson,Eyal David,Helene Strick-Marchand,Helene Strick-Marchand,Lionel Le Bourhis,Roberto Cocchi,Davide Topazio,Paolo Graziano,Lucia Anna Muscarella,Lars Rogge,Xavier Norel,Jean-Michel Sallenave,Matthieu Allez,Thomas Graf,Rudi W. Hendriks,Jean-Laurent Casanova,Ido Amit,Hans Yssel,James P. Di Santo,James P. Di Santo +40 more
TL;DR: The results support a model of tissue ILC differentiation ("ILC-poiesis"), whereby diverse ILC subsets are generated in situ from systemically distributed ILCPs in response to local environmental signals.
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Transcription factors and 3D genome conformation in cell-fate decisions
TL;DR: Three-dimensional genome architecture has important roles in the regulation of gene expression and is therefore a key determinant of cell identity in normal development and in disease states.
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Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma
Björn Lamprecht,Korden Walter,Stephan Kreher,Stephan Kreher,Raman Kumar,Michael Hummel,Dido Lenze,Karl Köchert,Karl Köchert,Mohamed Amine Bouhlel,Julia Richter,Eric Soler,Ralph Stadhouders,Korinna Jöhrens,Kathrin D. Wurster,Kathrin D. Wurster,David F. Callen,Michael F Harte,Maciej Giefing,Maciej Giefing,Rachael Barlow,Harald Stein,Ioannis Anagnostopoulos,Martin Janz,Martin Janz,Peter N. Cockerill,Reiner Siebert,Bernd Dörken,Bernd Dörken,Constanze Bonifer,Stephan Mathas,Stephan Mathas +31 more
TL;DR: It is concluded that LTR derepression is involved in the pathogenesis of human lymphomas, a finding that might have diagnostic, prognostic and therapeutic implications.
Journal ArticleDOI
Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming
Ralph Stadhouders,Ralph Stadhouders,Enrique Vidal,François Serra,Bruno Di Stefano,Bruno Di Stefano,François Le Dily,Javier Quilez,Antonio Gomez,Samuel Collombet,Clara Berenguer,Yasmina Cuartero,Jochen Hecht,Guillaume J. Filion,Miguel Beato,Marc A. Marti-Renom,Thomas Graf +16 more
TL;DR: It is concluded that 3D genome reorganization generally precedes gene expression changes and that removal of locus-specific topological barriers explains why pluripotency genes are activated sequentially during reprogramming.
Journal ArticleDOI
The Effect of Primer-Template Mismatches on the Detection and Quantification of Nucleic Acids Using the 5′ Nuclease Assay
Ralph Stadhouders,Suzan D. Pas,Jeer Anber,Jolanda J.C. Voermans,Ted H.M. Mes,Martin Schutten +5 more
TL;DR: The data suggest that mismatch impact follows a consistent pattern and enabled us to formulate several guidelines for predicting primer-template mismatch behavior when using specific 5-nuclease assay master mixes, which should allow for more optimized development of real-time PCR assays involving primer- template mismatches.