C
Christelle Peyron
Researcher at University of Lyon
Publications - 69
Citations - 13913
Christelle Peyron is an academic researcher from University of Lyon. The author has contributed to research in topics: Narcolepsy & Orexin. The author has an hindex of 31, co-authored 64 publications receiving 12969 citations. Previous affiliations of Christelle Peyron include Stanford University & Centre national de la recherche scientifique.
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Journal ArticleDOI
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
L de Lecea,Thomas S. Kilduff,Christelle Peyron,Xiao-Bing Gao,Pamela E. Foye,Patria E. Danielson,C. Fukuhara,Elena Battenberg,Vigdis T. Gautvik,Frederick S. Bartlett,Wayne N. Frankel,A. N. van den Pol,Floyd E. Bloom,Kaare M. Gautvik,J G Sutcliffe +14 more
TL;DR: A hypothalamus-specific mRNA is described that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin, suggesting that the hypocretins function within the CNS as neurotransmitters.
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Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
Christelle Peyron,Devin K. Tighe,Anthony N. van den Pol,Anthony N. van den Pol,Luis de Lecea,H. Craig Heller,J. Gregor Sutcliffe,Thomas S. Kilduff +7 more
TL;DR: The results of this immunohistochemical study suggest that hypocretins are likely to have a role in physiological functions in addition to food intake such as regulation of blood pressure, the neuroendocrine system, body temperature, and the sleep–waking cycle.
Journal ArticleDOI
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
Christelle Peyron,Juliette Faraco,William J. Rogers,Beth Ripley,Sebastiaan Overeem,Sebastiaan Overeem,Yves Charnay,Sona Nevsimalova,Michael S. Aldrich,David Reynolds,Roger L. Albin,Robin Li,Marcel Hungs,Mario Pedrazzoli,Muralidhara Padigaru,Melanie H. Kucherlapati,Jun Fan,Richard A. Maki,Gert Jan Lammers,Constantin Bouras,Raju Kucherlapati,Seiji Nishino,Emmanuel Mignot +22 more
TL;DR: In situ hybridization of the perifornical area and peptide radioimmunoassays indicated global loss of hypocretins, without gliosis or signs of inflammation in all human cases examined, indicating most cases of human narcolepsy are associated with a deficient hypocretin system.
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Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system.
Tamas L. Horvath,Christelle Peyron,Sabrina Diano,Alexander Ivanov,Gary Aston-Jones,Thomas S. Kilduff,Anthony N. van den Pol,Anthony N. van den Pol +7 more
TL;DR: The present results provide evidence for direct action of hypothalamic hypocretin cells on the LC noradrenergic system in rats and monkeys and suggest a signaling pathway via which signals acting on the lateral hypothalamus may influence the activity of the LC and thereby a variety of CNSfunctions related to noradRenergic innervation.
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Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods
TL;DR: The forebrain afferents to the dorsal raphe nucleus are re-examined using cholera toxin b subunit and Phaseolus vulgaris-leucoagglutinin as retrograde or anterograde tracers and a substantial to large number of retrogradely-labelled cells are observed in the central nucleus of the amygdala following tracer injections.