E
Eric L. Bell
Researcher at Massachusetts Institute of Technology
Publications - 36
Citations - 8223
Eric L. Bell is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Hypoxia-inducible factors & Mitochondrion. The author has an hindex of 27, co-authored 36 publications receiving 7074 citations. Previous affiliations of Eric L. Bell include Northwestern University.
Papers
More filters
Journal ArticleDOI
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Christian M. Metallo,Paulo A. Gameiro,Eric L. Bell,Katherine R. Mattaini,Juanjuan Yang,Karsten Hiller,Karsten Hiller,Christopher M. Jewell,Zachary R. Johnson,Darrell J. Irvine,Darrell J. Irvine,Leonard Guarente,Joanne K. Kelleher,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Othon Iliopoulos,Gregory Stephanopoulos +16 more
TL;DR: It is shown that human cells use reductive metabolism of α-ketoglutarate to synthesize AcCoA for lipid synthesis and support lipid synthesis in mammalian cells.
Journal ArticleDOI
Declining NAD + Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
Ana P. Gomes,Ana P. Gomes,Nathan L. Price,Alvin J. Y. Ling,Javid Moslehi,Magdalene K. Montgomery,Luis A. Rajman,James P. White,João S. Teodoro,Christiane D. Wrann,Basil P. Hubbard,Evi M. Mercken,Carlos M. Palmeira,Rafael de Cabo,Anabela P. Rolo,Nigel Turner,Eric L. Bell,David A. Sinclair,David A. Sinclair +18 more
TL;DR: It is shown that, during aging, there is a specific loss of mitochondrial, but not nuclear, encoded OXPHOS subunits, and an alternate PGC-1α/β-independent pathway of nuclear-mitochondrial communication contributes to the decline in mitochondrial function with age.
Journal ArticleDOI
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
Joslyn K. Brunelle,Eric L. Bell,Nancy Quesada,Kristel Vercauteren,Valeria Tiranti,Massimo Zeviani,Richard C. Scarpulla,Navdeep S. Chandel +7 more
TL;DR: It is shown that a small interfering RNA (siRNA) against the Rieske iron-sulfur protein of mitochondrial complex III prevents the hypoxic stabilization of HIF-1 alpha protein.
Journal ArticleDOI
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
Eric L. Bell,Tatyana A. Klimova,James Eisenbart,Carlos T. Moraes,Michael P. Murphy,G. R. Scott Budinger,Navdeep S. Chandel +6 more
TL;DR: Genetic and pharmacologic evidence is provided that the Qo site of complex III is required for the transduction of hypoxic signal by releasing ROS to stabilize the HIF-1α protein.
Journal ArticleDOI
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
TL;DR: This paper showed that the mitochondrial sirtuin, SirT3, acts as a tumor suppressor via its ability to suppress reactive oxygen species (ROS) and regulate hypoxia inducible factor 1α (HIF-1α).