N
Nicole Gas
Researcher at Centre national de la recherche scientifique
Publications - 41
Citations - 3917
Nicole Gas is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Nucleolus & Dense fibrillar component. The author has an hindex of 27, co-authored 41 publications receiving 3753 citations. Previous affiliations of Nicole Gas include Paul Sabatier University.
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Journal ArticleDOI
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis
Aurélien Olichon,Laurent Baricault,Nicole Gas,Emmanuelle Guillou,Annie Valette,Pascale Belenguer,Guy Lenaers +6 more
TL;DR: It is suggested that OPA1 is a major organizer of the mitochondrial inner membrane from which the maintenance of the cristae integrity depends and that abnormal apoptosis is a possible pathophysiological process leading to the retinal ganglion cells degeneration in ADOA patients.
Journal ArticleDOI
The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space.
Aurélien Olichon,Laurent J. Emorine,Eric Descoins,Laetitia Pelloquin,Laetitia Brichese,Nicole Gas,Emmanuelle Guillou,Cécile Delettre,Annie Valette,Christian P. Hamel,Bernard Ducommun,Guy Lenaers,Pascale Belenguer +12 more
TL;DR: Immuno‐fluorescence and biochemical evidences are presented showing that OPA1 resides in the mitochondria where it is imported through its highly basic amino‐terminal extension.
Journal ArticleDOI
Maturation and Intranuclear Transport of Pre-Ribosomes Requires Noc Proteins
Philipp Milkereit,Olivier Gadal,Alexander Podtelejnikov,Stéphanie Trumtel,Nicole Gas,Elisabeth Petfalski,David Tollervey,Mathias Mann,Ed Hurt,Herbert Tschochner +9 more
TL;DR: It is proposed that the dynamic interaction of Noc proteins is crucial for intranuclear movement of ribosomal precursor particles, and, thereby represent a prerequisite for proper maturation.
Journal ArticleDOI
Sequential protein association with nascent 60S ribosomal particles.
Cosmin Saveanu,Abdelkader Namane,Pierre-Emmanuel Gleizes,Alice Lebreton,Jean-Claude Rousselle,Jacqueline Noaillac-Depeyre,Nicole Gas,Alain Jacquier,Micheline Fromont-Racine +8 more
TL;DR: It is shown here that the association of preribosomal factors with pre-60S complexes depends on the presence of earlier factors, a phenomenon essential for ribosome biogenesis.
Journal ArticleDOI
Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps
Cosmin Saveanu,David Bienvenu,Abdelkader Namane,Pierre-Emmanuel Gleizes,Nicole Gas,Alain Jacquier,Micheline Fromont-Racine +6 more
TL;DR: The results suggest that transient, possibly GTP‐dependent association of Nog2p with the pre‐ribosomes might trigger late rRNA maturation steps in ribosomal large subunit biogenesis.