C
Christian Spenger
Researcher at Karolinska Institutet
Publications - 105
Citations - 7149
Christian Spenger is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Spinal cord & Spinal cord injury. The author has an hindex of 48, co-authored 105 publications receiving 6729 citations. Previous affiliations of Christian Spenger include Karolinska University Hospital & AstraZeneca.
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Journal ArticleDOI
Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome
Christoph P. Hofstetter,Niklas Holmström,Johan Lilja,Petra Schweinhardt,Petra Schweinhardt,Jinxia Hao,Christian Spenger,Zsuzsanna Wiesenfeld-Hallin,Shekar N. Kurpad,Jonas Frisén,Lars Olson +10 more
TL;DR: Evidence is provided that grafting of adult neural stem cells into a rat thoracic spinal cord weight-drop injury improves motor recovery but also causes aberrant axonal sprouting associated with allodynia-like hypersensitivity of forepaws.
Journal ArticleDOI
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
Madhav Thambisetty,Andrew Simmons,Latha Velayudhan,Abdul Hye,James Campbell,Yi Zhang,Lars-Olof Wahlund,Eric Westman,Anna Kinsey,Andreas Güntert,Petroula Proitsi,John Powell,Mirsada Causevic,Richard Killick,Katie Lunnon,Steven Lynham,Martin Broadstock,Fahd Choudhry,David R. Howlett,Robert J. Williams,Sally I. Sharp,Cathy Mitchelmore,Catherine Tunnard,Rufina Leung,Catherine Foy,Darragh O'Brien,Gerome Breen,Simon J. Furney,Malcolm Ward,Iwona Kłoszewska,Patrizia Mecocci,Hilkka Soininen,Magda Tsolaki,Bruno Vellas,Angela Hodges,Declan G. Murphy,Sue Parkins,Jill C. Richardson,Susan M. Resnick,Luigi Ferrucci,Dean F. Wong,Yun Zhou,Sebastian Muehlboeck,Alan C. Evans,Paul T. Francis,Christian Spenger,Simon Lovestone +46 more
TL;DR: These results demonstrate an important role of clusterin in the pathogenesis of AD and suggest that alterations in amyloid chaperone proteins may be a biologically relevant peripheral signature of AD.
Journal ArticleDOI
A template for spatial normalisation of MR images of the rat brain.
TL;DR: The preparation of a rat template intended for use together with SPM to enable spatial normalisation of individual rat brains to facilitate reporting results in co-ordinates directly corresponding to the Paxinos co-ordinate system is described.
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Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment
Sergi G. Costafreda,Ivo D. Dinov,Zhuowen Tu,Yonggang Shi,Cheng-Yi Liu,Iwona Kłoszewska,Patrizia Mecocci,Hilkka Soininen,Magda Tsolaki,Bruno Vellas,Lars-Olof Wahlund,Christian Spenger,Arthur W. Toga,Simon Lovestone,Andrew Simmons +14 more
TL;DR: It is concluded that automated shape analysis generates sensitive measurements of early neurodegeneration which predates the onset of dementia and thus provides a prognostic biomarker for conversion of MCI to AD.
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AddNeuroMed—The European Collaboration for the Discovery of Novel Biomarkers for Alzheimer's Disease
Simon Lovestone,Paul T. Francis,Iwona Kłoszewska,Patrizia Mecocci,Andrew Simmons,Hilkka Soininen,Christian Spenger,Magda Tsolaki,Bruno Vellas,Lars-Olof Wahlund,Malcolm Ward +10 more
TL;DR: The development and design of AddNeuroMed and the progress toward the development of plasma markers show that plasma markers are feasible and animal models are valuable in biomarker research.