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Simon J. Furney
Researcher at King's College London
Publications - 44
Citations - 3205
Simon J. Furney is an academic researcher from King's College London. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 25, co-authored 38 publications receiving 2812 citations. Previous affiliations of Simon J. Furney include University College Dublin & Institute of Cancer Research.
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Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
Madhav Thambisetty,Andrew Simmons,Latha Velayudhan,Abdul Hye,James Campbell,Yi Zhang,Lars-Olof Wahlund,Eric Westman,Anna Kinsey,Andreas Güntert,Petroula Proitsi,John Powell,Mirsada Causevic,Richard Killick,Katie Lunnon,Steven Lynham,Martin Broadstock,Fahd Choudhry,David R. Howlett,Robert J. Williams,Sally I. Sharp,Cathy Mitchelmore,Catherine Tunnard,Rufina Leung,Catherine Foy,Darragh O'Brien,Gerome Breen,Simon J. Furney,Malcolm Ward,Iwona Kłoszewska,Patrizia Mecocci,Hilkka Soininen,Magda Tsolaki,Bruno Vellas,Angela Hodges,Declan G. Murphy,Sue Parkins,Jill C. Richardson,Susan M. Resnick,Luigi Ferrucci,Dean F. Wong,Yun Zhou,Sebastian Muehlboeck,Alan C. Evans,Paul T. Francis,Christian Spenger,Simon Lovestone +46 more
TL;DR: These results demonstrate an important role of clusterin in the pathogenesis of AD and suggest that alterations in amyloid chaperone proteins may be a biologically relevant peripheral signature of AD.
Journal ArticleDOI
SF3B1 Mutations Are Associated with Alternative Splicing in Uveal Melanoma
Simon J. Furney,Malin Pedersen,David Gentien,Amaury Dumont,Audrey Rapinat,Laurence Desjardins,Samra Turajlic,Sophie Piperno-Neumann,Pierre de la Grange,Sergio Roman-Roman,Marc-Henri Stern,Richard Marais +11 more
TL;DR: It is shown that SF3B1 is recurrently mutated in uveal melanoma, and the mutations are associated with aberrant alternative splicing, a relatively simple genetic disease characterized by recurrent chromosomal losses and gains and a low mutational burden.
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Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53
Amaya Viros,Berta Sanchez-Laorden,Malin Pedersen,Simon J. Furney,Joel Rae,Kate Hogan,Sarah Ejiama,Maria Romina Girotti,Martin G. Cook,Martin G. Cook,Nathalie Dhomen,Richard Marais +11 more
TL;DR: It is shown that sunscreen (UVA superior, UVB sun protection factor (SPF) 50) delayed the onset of UVR-driven melanoma, but only provided partial protection, validates public health campaigns that promote sunscreen protection for individuals at risk of melanoma.
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Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma
Maria Romina Girotti,Gabriela Gremel,Rebecca Lee,Elena Galvani,Dominic G. Rothwell,Amaya Viros,A. Mandal,Kok Haw Jonathan Lim,Grazia Saturno,Simon J. Furney,Franziska Baenke,Malin Pedersen,Jane Rogan,Jacqueline Swan,Matthew R. Smith,Alberto Fusi,Deemesh Oudit,Nathalie Dhomen,Ged Brady,Paul Lorigan,Caroline Dive,Richard Marais +21 more
TL;DR: A powerful precision medicine platform to monitor patient responses and to identify and validate hypothesis-driven therapies for patients who do not respond, or who develop resistance to current treatments is developed.
Journal ArticleDOI
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway
Richard Killick,Elena M. Ribe,Raya Al-Shawi,Bilal Malik,Claudie Hooper,Chantelle Fernandes,Richard Dobson,Patrick M. Nolan,Anbarasu Lourdusamy,Simon J. Furney,Kuang Lin,Gerome Breen,Richard Wroe,Alvina W.M. To,Karelle Leroy,Mirsada Causevic,Alessia Usardi,Martha Robinson,Wendy Noble,Richard Williamson,Katie Lunnon,Stuart Kellie,Christopher A. Reynolds,Chantal Bazenet,Angela Hodges,J-P. Brion,John Stephenson,J. Paul Simons,Simon Lovestone +28 more
TL;DR: A pathway whereby Aβ induces a clusterin/p53/Dkk1/wnt–PCP–JNK pathway, which drives the upregulation of several genes that mediate the development of AD-like neuropathologies is identified, thereby providing new mechanistic insights into the action of Aβ in neurodegenerative diseases.