Catherine Foy

TL;DR: These results demonstrate an important role of clusterin in the pathogenesis of AD and suggest that alterations in amyloid chaperone proteins may be a biologically relevant peripheral signature of AD.

TL;DR: Results indicate that variants in the RPS3A homologue are associated with LOAD and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder.

TL;DR: GSK-3 protein was increased in both AD and in MCI without a compensatory decrease in activity and GSK-3 activity is increased in the prodromal phase of the disorder suggesting that inhibition of G SKS-3 might be a useful therapeutic strategy.

TL;DR: The association of plasma CFH and A2M with hippocampal NAA/mI in this cohort of AD subjects suggests that these proteins may reflect disease progression in early AD, and warrant validation in large population-based datasets.

TL;DR: LowerPremorbid agreeableness is associated with agitation and irritability symptoms in Alzheimer disease and also predicts an "agitation/apathy" syndrome, and premorbid neuroticism does not appear to be associated with depression in Alzheimer Disease or predict an "affect" syndrome.