C
Christian W. Heegaard
Researcher at Aarhus University
Publications - 67
Citations - 2356
Christian W. Heegaard is an academic researcher from Aarhus University. The author has contributed to research in topics: Lactadherin & Plasminogen activator. The author has an hindex of 26, co-authored 64 publications receiving 2145 citations. Previous affiliations of Christian W. Heegaard include United States Department of Veterans Affairs & Brigham and Women's Hospital.
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Journal ArticleDOI
Inhibitory effects of human and bovine milk constituents on rotavirus infections.
A.S. Kvistgaard,Lone Tjener Pallesen,Carlos F. Arias,Susana López,Torben E. Petersen,Christian W. Heegaard,Jan T. Rasmussen +6 more
TL;DR: It is shown that human, and not bovine, lactadherin inhibits Wa rotavirus infection in vitro, and a bovina macromolecular whey protein fraction turned out to have an efficient and versatile inhibitory activity against rotav virus.
Journal ArticleDOI
Lactadherin binds selectively to membranes containing phosphatidyl-L-serine and increased curvature.
TL;DR: The membrane-binding properties that correlate to the anticoagulant capacity are characterized and lactadherin resembles factor VIII and V with stereoselective preference for phosphatidyl-L-serine and preference for highly curved membranes.
Journal ArticleDOI
Interactions of Multiple Heparin Binding Growth Factors with Neuropilin-1 and Potentiation of the Activity of Fibroblast Growth Factor-2
David C. West,Chris G. Rees,Laurence Duchesne,Susannah J. Patey,Carla J. Terry,Jeremy E. Turnbull,Maryse Delehedde,Christian W. Heegaard,Fabrice Allain,Christophe Vanpouille,Dina Ron,David G. Fernig +11 more
TL;DR: The results suggest that Npn-1 possesses a “heparin” mimetic site that is able to interact at least in part through ionic bonding with the heparin binding site on many of the proteins studied.
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In vitro digestion of novel milk protein ingredients for use in infant formulas: Research on biological functions
Dereck E. W. Chatterton,Dereck E. W. Chatterton,Jan T. Rasmussen,Christian W. Heegaard,Esben S. Sørensen,Thor Petersen +5 more
TL;DR: In vitro digestion of milk proteins by human neonatal gastric juice at pH values representing those in early neonatal life was investigated to provide rapid information regarding the susceptibility of proteins to gastric proteases and is a convenient alternative to clinical studies.
Journal ArticleDOI
Very Low Density Lipoprotein Receptor Binds and Mediates Endocytosis of Urokinase-type Plasminogen Activator-Type-1 Plasminogen Activator Inhibitor Complex
Christian W. Heegaard,Anna Carina Wiborg Simonsen,Kazuhiro Oka,Lars Kj,Anni Christensen,Bente Madsen,Lars Ellgaard,Lawrence Chan,Peter A. Andreasen +8 more
TL;DR: Results show that VLDL-R represents a novel endocytosis mechanism for U-PA receptor-bound u-PA•PAI-1, which is significantly higher than non-transfected parental CHO cells and partially inhibited by DFP-u-PA.