Christina S. Kong

TL;DR: It is shown that LOX expression is regulated by hypoxia-inducible factor (HIF) and is associated with Hypoxia in human breast and head and neck tumours, and is a good therapeutic target for preventing and treating metastases.

TL;DR: A multidisciplinary panel comprised principally of radiologists and pulmonologists from 10 countries with experience managing COVID-19 patients across a spectrum of healthcare environments evaluated the utility of imaging within three scenarios representing varying risk factors, community conditions, and resource constraints, resulting in five main and three additional recommendations intended to guide medical practitioners in the use of CXR and CT in the management of COIDs.

TL;DR: Patients with p 16-negative non-OPSCC have worse outcomes than patients with p16-positive non-opsCC, and HPV may also have a role in outcome in a subset of non-OPSC, however, further development of a p16 IHC scoring system in non- OPSCC and improvement of HPV detection methods are warranted.

TL;DR: It is shown that Notch signalling can be both tumour suppressive and pro-tumorigenic in small-cell lung cancer, and the presence of these cells may serve as a biomarker for the use of Notch pathway inhibitors in combination with chemotherapy in select patients with small- cell lung cancer.

TL;DR: The identification of widespread chromatin changes during SCLC progression reveals an unexpected global reprogramming during metastatic progression, and indicates that Nfib is necessary and sufficient to increase chromatin accessibility at a large subset of the intergenic regions.